PXD051319

PXD051319 is an original dataset announced via ProteomeXchange.

Title	High-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor
Description	While international consensus and the 2021 WHO classification recognize multiple molecular medulloblastoma subgroups, these are difficult to identify in current clinical practice. As a result, biology driven risk stratification and therapy assignment for medulloblastoma constitutes a major challenge. Here, we report mass spectrometry analysis of clinical samples as a method for medulloblastoma subgroup discovery and identify MYC immunohistochemistry (IHC) as a clinically tractable method for improved risk stratification.
HostingRepository	PRIDE
AnnounceDate	2025-03-06
AnnouncementXML	Submission_2025-03-06_09:13:21.533.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christopher Hughes
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-09 15:35:19	ID requested
⏵ 1	2025-03-06 09:13:22	announced

10.1093/neuonc/noaf046;

Delaidelli A, Burwag F, Ben-Neriah S, Suk Y, Shyp T, Kosteniuk S, Dunham C, Cheng S, Okonechnikov K, Schrimpf D, von Deimling A, Ellezam B, Perreault S, Singh S, Hawkins C, Kool M, Pfister SM, Steidl C, Hughes C, Korshunov A, Sorensen PH, High-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy-resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor. Neuro Oncol, 27(9):2431-2444(2025) [pubmed]

submitter keyword: medulloblastoma, DIA,proteomics, MYC, immunohistochemistry

Christopher Hughes
contact affiliation	Manager, Biological Mass Spectrometry CORE
contact email	christopher.hughes@dal.ca
lab head
Christopher Hughes
contact affiliation	Dalhousie University
contact email	christopher.hughes@dal.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD051319

PRIDE project URI

• PRIDE
  1. PXD051319
     1. Label: PRIDE project
     2. Name: High-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor