⮝ Full datasets listing

PXD051304

PXD051304 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChromatomes of GR and SUMO2/3 identified with RIME
DescriptionWe identified GR and SUMO2/3 chromatomes in B-cell acute leukemia cells (NALM6) and studied the impact of SUMOylation inhibition (SUMOi) on them utilizing small molecule inhibitor ML792. Chromatome members were identified with Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (RIME) in absence and presence of the synthetic glucocorticoid dexamethasone (Dex) and ML792. Mass spectrometry analyses were executed with high resolution mass spectrometry (LC-MS), using the Evosep One liquid chromatography system coupled to a hybrid trapped ion mobility quadrupole TOF mass spectrometer (Bruker timsTOF Pro) via a CaptiveSpray nano-electrospray ion source. Chromatome members were discriminated from background based on spectral count expression filtering and intensity ratio compared to corresponding IgG control sample.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_13:41:27.208.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEmma Valima
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListbiotinylated residue; acetylated residue; monohydroxylated residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-09 05:43:39ID requested
12025-05-06 13:41:28announced
Publication List
Valima E, Varis V, Bureiko K, Lempi, รค, inen JK, Schroderus AM, Oksa L, Lohi O, Kinnunen T, Varjosalo M, Niskanen EA, Paakinaho V, Palvimo JJ, SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells. Oncogene, 44(18):1259-1271(2025) [pubmed]
10.1038/s41388-025-03305-3;
Keyword List
submitter keyword: Human, Cancer, Immunoprecipitation, Mass spectrometry, Chromatin
Contact List
Jorma Palvimo
contact affiliationInstitute of Biomedicine, University of Eastern Finland, Finland
contact emailjorma.palvimo@uef.fi
lab head
Emma Valima
contact affiliationUniversity of Eastern Finland
contact emailemma.valima@uef.fi
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051304
PRIDE project URI
Repository Record List
[ + ]