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PXD051266

PXD051266 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative Mass Spectrometry Analysis of the Injured Proximal and Distal Human Digital Nerve Ends
DescriptionProteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, concentrating on differences in protein expression between the proximal and distal nerve ends. A total of 26 human injured digital nerve samples (24 men; 2 women; median age 47 [30-66] years), harvested during primary nerve repair within 48 hours post-injury from proximal and distal nerve ends, were analyzed using mass spectrometry. A total of 3914 proteins were identified, with 127 proteins showing significant differences in abundance between the proximal and the distal nerve ends. The downregulation of proteins in the distal nerve end was associated with synaptic transmission, autophagy, neurotransmitter regulation, cell adhesion and migration. Conversely, proteins upregulated in the distal nerve end were implicated in cellular stress response, neuromuscular junction stability and muscle contraction, neuronal excitability and neurotransmitter release, synaptic vesicle recycling and axon guidance and angiogenesis. Investigation of proteins, with functional annotations analysis, in proximal and the distal ends of human injured digital nerves, revealed dynamic cellular responses aimed at promoting tissue degeneration and restoration, while suppressing non-essential processes.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:50:59.735.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCharlotte Welinder
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-08 01:21:00ID requested
12024-07-19 07:42:32announced
22024-10-22 06:51:00announced2024-10-22: Updated project metadata.
Publication List
Frostadottir D, Welinder C, Perez R, Dahlin LB, Quantitative mass spectrometry analysis of the injured proximal and distal human digital nerve ends. Front Mol Neurosci, 17():1425780(2024) [pubmed]
10.3389/fnmol.2024.1425780;
Keyword List
submitter keyword: Digital nerve injury, Quantitative Mass Spectrometry, Signal transduction, Peripheral nerve injury, Nerve injury pathways, Extracellular matrix, Proteomics
Contact List
Drifa Frostadottir
contact affiliationDepartment of Translational Medicine – Hand Surgery, Lund University, Malmö, Sweden
contact emaildrifa.frostadottir@med.lu.se
lab head
Charlotte Welinder
contact affiliationDept. of Oncology, Clinical Sciences, Lund University, 221 85 Lund, Sweden
contact emailcharlotte.welinder@med.lu.se
dataset submitter
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Dataset FTP location
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