PXD051260 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria. |
Description | The malaria-causing parasite Plasmodium has a complex life cycle involving both vertebrate and mosquito hosts. Sexual stages or gametocytes are the only stage competent for mosquito transmission. Gametogenesis of the male gametocyte requires rapid rounds of genome replication to form flagellated gametes. Here, we describe the discovery of a non-canonical Plasmodium actin-related protein 2/3 (Arp2/3) complex essential for DNA segregation during male gametogenesis. Plasmodium Arp2/3 dynamically localizes within the nucleus to the endomitotic spindle and interacts with a kinetochore protein. Deletion of key Arp2/3 subunits or interfering with actin polymerisation leads to the formation of sub-haploid male gametes and a complete block in transmission through delayed developmental arrest at the oocyst stage. Our work identified an evolutionary divergent protein complex in malaria parasites that offers potential targets for transmission-blocking interventions. |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-22 |
AnnouncementXML | Submission_2025-04-22_05:22:10.376.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marcin Luzarowski |
SpeciesList | scientific name: Plasmodium berghei; NCBI TaxID: 5821; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-04-07 22:28:29 | ID requested | |
⏵ 1 | 2025-04-22 05:22:10 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Arp2/3 complex, chromosome segregation,Malaria, Plasmodium |
Contact List
Franziska Hentzschel |
contact affiliation | Integrative Parasitology, Centre for Infectious Diseases, University Hospital Heidelberg, Heidelberg University Medical Faculty; Heidelberg, Germany |
contact email | franziska.hentzschel@med.uni-heidelberg.de |
lab head | |
Marcin Luzarowski |
contact affiliation | University of Heidelberg |
contact email | m.luzarowski@zmbh.uni-heidelberg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD051260 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051260
- Label: PRIDE project
- Name: A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.