PXD051155

PXD051155 is an original dataset announced via ProteomeXchange.

Title	Analysis of Brain Protein Stability Changes in Mouse Models of Alzheimer’s Disease
Description	. This study employed different mass spectrometry-based proteomic methods to characterize Alzheimer's Disease (AD) research by examining protein folding and stability in mouse models, offering a fresh perspective beyond traditional protein expression level analysis. Stability of Proteins from Rates of Oxidation (SPROX), Thermal Proteome Profiling (TPP), and Limited Proteolysis (LiP) are used to profile protein stability and conformational change in the hippocampus tissue cell lysates between wild type (n=7) and 5XFAD transgenic (n=7) mice at two time points (t1=2-month, t2=8-month).
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-12_16:48:48.386.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yun Tang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; methylthiolated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-02 12:26:36	ID requested
⏵ 1	2025-10-12 16:48:49	announced

10.1021/acs.jproteome.4c00406;

Tang Y, Park HJ, Li S, Fitzgerald MC, Analysis of Brain Protein Stability Changes in a Mouse Model of Alzheimer's Disease. J Proteome Res, 23(10):4443-4456(2024) [pubmed]

submitter keyword: proteomics,Alzheimer’s Disease, mass spectrometry, TPP, SPROX, LiP

Michael C. Fitzgerald
contact affiliation	Duke University Depratment of Chemistry
contact email	michael.c.fitzgerald@duke.edu
lab head
Yun Tang
contact affiliation	Duke University
contact email	yun.tang@duke.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD051155

PRIDE project URI

• PRIDE
  1. PXD051155
     1. Label: PRIDE project
     2. Name: Analysis of Brain Protein Stability Changes in Mouse Models of Alzheimer’s Disease