PXD051145

PXD051145 is an original dataset announced via ProteomeXchange.

Title	The aging Substantia nigra is characterized by ROS accumulation potentially resulting in a perturbed mitochondrial homeostasis, increased neuroinflammation and cytoskeletal remodelling
Description	Ageing is a progressive and irreversible process that ultimately leads to death, serving as the primary risk factor for neurodegenerative disorders. This study aims to identify the molecular mechanisms underlying physiological ageing within the substantia nigra, which is primarily affected in Parkinson's disease and to draw potential conclusions on the earliest events leading to neurodegeneration in this specific brain region. The characterisation of essential stages in ageing progress could enhance knowledge of the mechanisms that promote the development of Parkinson's disease. To gain a comprehensive overview we utilized three study groups young individuals with a mean age of 28.7, middle-aged with a mean age of 62.3 and elderly individuals (mean age: 83.9). Using our proteomic approach, we were able to identify crucial features of physiological aging. These include heightened oxidative stress, enhanced lysosomal degradation, autophagy, remodelling of the cytoskeleton, changes in the structure of the mitochondria, alterations in vesicle transportation, and synaptic plasticity.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_14:09:38.147.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Britta Eggers
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-02 03:10:07	ID requested
⏵ 1	2025-05-06 14:09:39	announced

10.1002/adbi.202400814;

Eggers B, Steinbach S, Aldea IG, Keers S, Molina M, Grinberg LT, Heinsen H, Paraizo Leite RE, Attems J, May C, Marcus K, The Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling. Adv Biol (Weinh), 9(4):e2400814(2025) [pubmed]

submitter keyword: laser microdissection,substantia nigra, proteomics, DIA, aging

Katrin Marcus
contact affiliation	Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany
contact email	katrin.marcus@rub.de
lab head
Britta Eggers
contact affiliation	Ruhr University Bochum
contact email	britta.eggers@rub.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051145

PRIDE project URI

• PRIDE
  1. PXD051145
     1. Label: PRIDE project
     2. Name: The aging Substantia nigra is characterized by ROS accumulation potentially resulting in a perturbed mitochondrial homeostasis, increased neuroinflammation and cytoskeletal remodelling