PXD051092

PXD051092 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Single-cell proteomics captures the Proteome Heterogeneity in Human iPSC-Derived Cardiomyocytes and Adult Cardiomyocytes
Description	Human induced pluripotent stem cell (IPSC)-derived cardiomyocytes (iCMs) have become important tools to model cardiovascular diseases and drug toxicology. Despite suggested transcriptomic heterogeneity in both iPSC and iCMs, the cellular proteome heterogeneity is poorly understood. Using cutting-edge single cell proteomics, we quantify the maturation from IPSC to iCMs and observed two distinct populations of iCMs with different metabolism, which recapitulates the single adult cardiomyocyte proteome populations albeit less mature.
HostingRepository	MassIVE
AnnounceDate	2025-02-06
AnnouncementXML	Submission_2025-02-06_10:43:30.546.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aleksandra Binek
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF SCP

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-29 12:46:33	ID requested
⏵ 1	2025-02-06 10:43:30	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: iPSCs, CMs, differentiation, single cell

submitter keyword: iPSCs, CMs, differentiation, single cell

Contact List

Jennifer Van Eyk
contact affiliation	Cedars Sinai Medical Center
contact email	jennifer.vaneyk@cshs.org
lab head
Aleksandra Binek
contact affiliation	Cedars Sinai Medical Center
contact email	bineka@cshs.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094438/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094438/