PXD051092
PXD051092 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Single-cell proteomics captures the Proteome Heterogeneity in Human iPSC-Derived Cardiomyocytes and Adult Cardiomyocytes |
Description | Human induced pluripotent stem cell (IPSC)-derived cardiomyocytes (iCMs) have become important tools to model cardiovascular diseases and drug toxicology. Despite suggested transcriptomic heterogeneity in both iPSC and iCMs, the cellular proteome heterogeneity is poorly understood. Using cutting-edge single cell proteomics, we quantify the maturation from IPSC to iCMs and observed two distinct populations of iCMs with different metabolism, which recapitulates the single adult cardiomyocyte proteome populations albeit less mature. |
HostingRepository | MassIVE |
AnnounceDate | 2025-02-06 |
AnnouncementXML | Submission_2025-02-06_10:43:30.546.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aleksandra Binek |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF SCP |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-29 12:46:33 | ID requested | |
⏵ 1 | 2025-02-06 10:43:30 | announced |
Publication List
no publication |
Keyword List
submitter keyword: iPSCs, CMs, differentiation, single cell |
Contact List
Jennifer Van Eyk | |
---|---|
contact affiliation | Cedars Sinai Medical Center |
contact email | jennifer.vaneyk@cshs.org |
lab head | |
Aleksandra Binek | |
contact affiliation | Cedars Sinai Medical Center |
contact email | bineka@cshs.org |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094438/ |