PXD051063

PXD051063 is an original dataset announced via ProteomeXchange.

Title	Comana monomorpha caterpillar venom proteomics
Description	Zygaenoidea is a superfamily of lepidopterans containing many venomous species, including the Limacodidae (nettle caterpillars) and Megalopygidae (asp caterpillars). Venom proteomes have been recently documented for several species from each of these families, but further data are required to understand the evolution of venom in Zygaenoidea. In this study, we examined the 'electric' caterpillar from North-Eastern Australia, a limacodid caterpillar densely covered in venomous spines. We used DNA barcoding to identify this caterpillar as the larva of the moth Comana monomorpha (Turner, 1904). We report the clinical symptoms of C. monomorpha envenomation, which include acute pain and erythema and oedema lasting for more than a week. Combining transcriptomics of venom spines with proteomics of venom harvested from the spine tips revealed a venom markedly different in composition from previously examined limacodid venoms that are rich in peptides. In contrast, the venom of C. monomorpha is rich in aerolysin-like proteins similar to those found in venoms of asp caterpillars (Megalopygidae). Consistent with this composition, the venom potently permeabilises sensory neurons and human neuroblastoma cells. This study highlights the diversity of venom composition in Limacodidae.
HostingRepository	PRIDE
AnnounceDate	2024-05-29
AnnouncementXML	Submission_2024-05-29_02:43:13.787.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mohaddeseh Goudarzi
SpeciesList	scientific name: Comana monomorpha; NCBI TaxID: 1555636;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-28 09:42:39	ID requested
⏵ 1	2024-05-29 02:43:14	announced

Dataset with its publication pending

submitter keyword: venom,Caterpillar, Limacodid

Glenn King
contact affiliation	Group Leader, Institute for Molecular Biosciences, The University of Queensland, Australia
contact email	glenn.king@imb.uq.edu.au
lab head
Mohaddeseh Goudarzi
contact affiliation	The University of Queensland
contact email	ihedy.m@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD051063
     1. Label: PRIDE project
     2. Name: Comana monomorpha caterpillar venom proteomics