PXD051045

PXD051045 is an original dataset announced via ProteomeXchange.

Title	Toxicological safety evaluation of diallyl trisulfide through acute and subacute toxicity studies in ICR mice
Description	Diallyl trisulfide (DATS) is one of the main sulfide-containing compounds in garlic oil and has been shown to have a variety of biological activities such as anti-tumor, inhibition of inflammation, and immune regulation. However, there is very little information available regarding its toxicological safety. To elucidate the toxicity mechanism and find the early warning biomarker of DATS, this study conducted acute and subacute toxicity experiments according to the OECD guidelines. The potential serum biomarker and toxicity mechanism of DATS were explored by proteomics.
HostingRepository	iProX
AnnounceDate	2024-03-28
AnnouncementXML	Submission_2025-01-20_23:26:27.005.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yihao Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-27 23:03:44	ID requested
⏵ 1	2025-01-20 23:26:27	announced

Wu Z, Tu B, Li S, Chen J, Shen P, Zhou W, Ma Z, Tang X, Xiao C, Wang Y, Gao Y, Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments. J Ethnopharmacol, 338(Pt 3):119102(2025) [pubmed]

submitter keyword: diallyl trisulfide, acute and subacute toxicity studies, ICR mice, serum, spleen

Yue Gao
contact affiliation	Beijing Institute of Radiation Medicine
contact email	gaoyue@bmi.ac.cn
lab head
Yihao Wang
contact affiliation	Beijing Institute of Radiation Medicine
contact email	hao_1216@126.com
dataset submitter

iProX dataset URI