PXD051044

PXD051044 is an original dataset announced via ProteomeXchange.

Title	Enhancing CAR T-cell efficacy against neuroblastoma through MIF inhibition
Description	Neuroblastoma is a common pediatric extracranial solid tumor, that arises in the developing sympathetic nervous system. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated promising clinical responses, yet its effectiveness in neuroblastoma benefits only a subset of patients. We evaluated the immunosuppressive secretome of neuroblastoma tumoroids that attenuate CAR T-cells function and efficacy. Secreted proteins were collected from tumoroids and identified by shotgun MS.
HostingRepository	PRIDE
AnnounceDate	2025-04-02
AnnouncementXML	Submission_2025-04-01_21:08:27.849.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elisavet Kalaitsidou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-27 21:40:21	ID requested
⏵ 1	2025-04-01 21:08:28	announced

10.1016/J.EJCA.2025.115263;

submitter keyword: Organoids, CAR-T cell,Neuroblastoma, Proteomics, Secretome

wei wu
contact affiliation	Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 138648 Singapore, Singapore. Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 117543, Singapore, Singapore.
contact email	wu_wei@immunol.a-star.edu.sg
lab head
Elisavet Kalaitsidou
contact affiliation	National University of Singapore, (SIgN), A*STAR
contact email	elisavet.k@u.nus.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD051044

PRIDE project URI

• PRIDE
  1. PXD051044
     1. Label: PRIDE project
     2. Name: Enhancing CAR T-cell efficacy against neuroblastoma through MIF inhibition