PXD050970

PXD050970 is an original dataset announced via ProteomeXchange.

Title	Transcriptomics coupled proteomics reveals the critical signaling pathways regulating OVA antigen-specific CD8+ T cells in mouse spleen and liver
Description	Antigen-specific T cells are particularly important for eliminating bacterial infection, and the dynamics in this process help uncover the mechanisms by which bacteria are eliminated.This study used MHC class I tetramers to recognize the antigen OVA antigen-specific CD8+ T cells in mouse spleen and liver. Then combined the RNAseq and LC-MS/MS analysis to track the changes of the OVA antigen-specific CD8+ T cells at different time points (5 days,7 days, and 14 days post listeria infection).Transcriptomics coupled proteomics reveals the key signaling pathways to regulate antigen-specific CD8+ T cells by infection of Listeria monocytogenes expressing the OVA protein in mouse spleen and liver.
HostingRepository	iProX
AnnounceDate	2024-03-26
AnnouncementXML	Submission_2024-03-25_23:57:48.621.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiangbei Yuan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-25 23:57:25	ID requested
⏵ 1	2024-03-25 23:57:49	announced

Dataset with its publication pending

submitter keyword: Listeria monocytogenes infection, CD8+ T cell, OVA antigen-specific, KEGG pathway analysis, RNAseq, LC-MS/MS

Jiangbei Yuan
contact affiliation	Zhejiang Provincial People's Hospital
contact email	yuanjiangbei@163.com
lab head
Jiangbei Yuan
contact affiliation	Zhejiang Provincial People's Hospital
contact email	yuanjiangbei@163.com
dataset submitter

iProX dataset URI