PXD050942

PXD050942 is an original dataset announced via ProteomeXchange.

Title	SUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells
Description	In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer and could provide a new theoretical basis for clinical treatment strategies.
HostingRepository	iProX
AnnounceDate	2024-03-25
AnnouncementXML	Submission_2025-08-26_19:50:42.223.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-24 22:46:57	ID requested
1	2025-06-29 21:11:30	announced
⏵ 2	2025-08-26 19:50:43	announced	2025-08-27: Add info.

Yang Y, Gu X, Weng W, Cheng J, Huang O, Pan SJ, Li Y, SUMOylation-induced membrane localization of TRPV1 suppresses proliferation and migration in gastric cancer cells. Cell Commun Signal, 22(1):465(2024) [pubmed]

submitter keyword: GC, TRPV1, SUMOylation, Membrane expression, AP2M1, AMPK

Yang Yang
contact affiliation	Shanghai Jiao Tong University
contact email	princess_yanggirl@alumni.sjtu.edu.cn
lab head
Yang Yang
contact affiliation	Shanghai Jiao Tong University
contact email	princess_yanggirl@alumni.sjtu.edu.cn
dataset submitter

iProX dataset URI