PXD050941

PXD050941 is an original dataset announced via ProteomeXchange.

Title	The role and mechanism of TRPV1 SUMOylation in inhibiting the proliferation and migration of gastric cancer cells
Description	In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer and could provide a new theoretical basis for clinical treatment strategies.
HostingRepository	iProX
AnnounceDate	2024-03-25
AnnouncementXML	Submission_2025-08-26_19:42:38.458.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-24 20:41:38	ID requested
⏵ 1	2025-08-26 19:42:39	announced

Yang Y, Gu X, Weng W, Cheng J, Huang O, Pan SJ, Li Y, SUMOylation-induced membrane localization of TRPV1 suppresses proliferation and migration in gastric cancer cells. Cell Commun Signal, 22(1):465(2024) [pubmed]

submitter keyword: GC, TRPV1, SUMOylation, Membrane expression, AP2M1, AMPK

Yang Yang
contact affiliation	Shanghai Jiao Tong University
contact email	princess_yanggirl@alumni.sjtu.edu.cn
lab head
Yang Yang
contact affiliation	Shanghai Jiao Tong University
contact email	princess_yanggirl@alumni.sjtu.edu.cn
dataset submitter

iProX dataset URI