PXD050859

PXD050859 is an original dataset announced via ProteomeXchange.

Title	TMTpro-SP3-LC-MS analysis of peritoneal dialysis effluent of a phase 2 randomized clinical trial
Description	Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guiding the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD. Here we use a high-performance multiplex proteomics approach based on depletion of highly abundant plasma proteins and enrichment of low abundance proteins for PDE samples from PD patients of a phase 2 randomized clinical trial, who received either standard PD fluid or a novel PD fluid (added alanyl-glutamine (AlaGln)) in an open-label, randomized, single-center, cross-over clinical trial.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_19:20:34.272.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Klaus Kratochwill
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-21 07:01:59	ID requested
⏵ 1	2026-04-26 19:20:35	announced

10.1016/j.ekir.2026.106342;

Herzog R, Daniel-Fischer L, Eibensteiner F, Sobieszek IJ, Unterwurzacher M, Sacnun JM, Uhl PKT, Lang E, Wagner A, K, ö, nig F, Alper SL, Davies LC, Aufricht C, Vychytil A, Kratochwill K, Local Immunometabolic Intervention With Alanyl-Glutamine Resolves Peritoneal Dialysis-Induced Immune Cell Dysfunction. Kidney Int Rep, 11(5):106342(2026) [pubmed]

submitter keyword: TMT,peritoneal dialysis

Dr Klaus Kratochwill
contact affiliation	Medical University of Vienna
contact email	klaus.kratochwill@meduniwien.ac.at
lab head
Klaus Kratochwill
contact affiliation	Medical University of Vienna
contact email	klaus.kratochwill@meduniwien.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD050859

PRIDE project URI

• PRIDE
  1. PXD050859
     1. Label: PRIDE project
     2. Name: TMTpro-SP3-LC-MS analysis of peritoneal dialysis effluent of a phase 2 randomized clinical trial