PXD050802

PXD050802 is an original dataset announced via ProteomeXchange.

Title	study of actin interactome in Alzheimers disease mouse model
Description	Filamentous actin (F-actin) is one of the major cytoskeleton proteins present in dendritic spines and it is an essential component for defining dendritic spine morphology. We have shown that synaptosomal F-actin levels were significantly decreased in APP/PS1 mice as early as one month of age. The molecular mechanisms involved in F-actin loss in synaptosomes, the underlying factors and the functional consequence involved needs to be elucidated. Synaptic neurotransmission and synaptic plasticity are dependent on the dynamic regulation of the actin through actin interacting and actin-modulating proteins. F-actin nanoarchitecture is regulated by several factors, such as reactive oxygen species and cofilin and others that are present in the dendritic spines. Yet, the key players and their role in synaptosomal F-actin organization remains unknown. Here, we characterized actin interactome from wild type and APP/PS1 male mice.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:45:47.957.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Reddy Peera Kommaddi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-20 02:31:49	ID requested
⏵ 1	2024-10-17 02:45:48	announced

10.1186/s13195-024-01558-w;

P A H, Basavaraju N, Chandran M, Jaleel A, Bennett DA, Kommaddi RP, Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer's disease. Alzheimers Res Ther, 16(1):200(2024) [pubmed]

submitter keyword: F-Actin loss, Alzheimers disease,synapse

Reddy Peera Kommaddi
contact affiliation	Senior Scientific Officer, Centre for Brain Research Indian Institute of Science Campus CV Raman Avenue Bangalore 560012. India.
contact email	reddy@iisc.ac.in
lab head
Reddy Peera Kommaddi
contact affiliation	Centre for Brain Research
contact email	reddy@iisc.ac.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD050802

PRIDE project URI

• PRIDE
  1. PXD050802
     1. Label: PRIDE project
     2. Name: study of actin interactome in Alzheimers disease mouse model