PXD050780

PXD050780 is an original dataset announced via ProteomeXchange.

Title	Cognitive Decline in Older Adults with Type 2 Diabetes: Unraveling Site-Specific Glycoproteomic Alterations
Description	Type 2 diabetes (T2D) is consistently associated with an elevated risk of cognitive decline and dementia. The underlying molecular mechanisms relating T2D to cognitive decline remain unclear, impeding the ability to detect the earliest stages of cognitive decline in older adults with T2D, consequently hindering advancement of preventive interventions. This study compared quantitative alterations in glycoproteoforms, represented by tryptic glycopeptiforms—specific glycan compositions on amino acid sites of proteins—in older T2D adults. We utilized label free, mass spectrometry-based glycoproteomics to analyze protein N-glycosylation and glycation patterns in serum samples, collected at two time points (T1 and T2), an average 52 months apart, from two initially cognitively healthy T2D groups. One group was comprised of individuals who experienced cognitive decline (“decliners”; N=8), and the other, of individuals who maintained normal cognition (“non-decliners”; N=14) over time. Comparison of these two groups revealed distinct patterns for glycosylation and glycation. Glycosylation primarily affected platelet function pathways. Glycation was also involved in immune system and platelet function along with various metabolic pathways. These findings suggest that aberrant glycoproteomic modifications may contribute to the development of cognitive impairment in T2D and may serve as potential early biomarkers. Further research is warranted to elucidate the functional implications of glycopeptiform modifications in T2D-related cognitive decline.
HostingRepository	PRIDE
AnnounceDate	2025-02-16
AnnouncementXML	Submission_2025-02-15_22:04:28.644.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD050780
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yishai Levin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	N-glycosylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-19 12:55:51	ID requested
⏵ 1	2025-02-15 22:04:29	announced

10.6019/PXD050780;

submitter keyword: glycosylation, glycation, Serum, glycoproteomics, Plasma,Cognition

Michal Schnaider Beeri
contact affiliation	The Herbert and Jackeline Krieger Klein Alzheimer's Research Center, Brain Health Institute, Rutgers University
contact email	michal.beeri@rutgers.edu
lab head
Yishai Levin
contact affiliation	Weizmann Institute of Science, Israel
contact email	yishai.levin@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050780
     1. Label: PRIDE project
     2. Name: Cognitive Decline in Older Adults with Type 2 Diabetes: Unraveling Site-Specific Glycoproteomic Alterations