PXD050765

PXD050765 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of acute pancreatitis in TRP14-KO miceProteomic analysis of acute pancreatitis in TRP14-KO mice
Description	We have studied pancreas samples in pancreas from a mouse model of acute pancreatitis, comparing wild-type animals and TRP14 KO animals. Samples are extracted with N-ethylmaleimide to block reduced cysteines, and no reducing agent is used, with a search including cysteinylated peptides. Acute pancreatitis was induced in 12 weeks-old mice (wild-type and KO for TRP14) by seven intraperitoneal injections of cerulein (50 µg/kg body weight) at 1 h intervals. Then, 1 h after the last injection, animals were euthanized under anesthesia with 3% isoflurane, exsanguinated, and the pancreas was immediately removed and processed.
HostingRepository	PRIDE
AnnounceDate	2024-05-15
AnnouncementXML	Submission_2024-05-15_10:02:17.183.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD050765
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Antonio Martínez Ruiz
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	cysteinylation (disulfide with free L-cysteine); N-ethylmaleimide derivatized cysteine; monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-19 06:21:13	ID requested
⏵ 1	2024-05-15 10:02:17	announced

Publication List

10.1038/S44318-024-00117-1;
10.6019/PXD050765;

10.1038/S44318-024-00117-1;

10.6019/PXD050765;

Keyword List

submitter keyword: mouse model, cysteine, disulfide exchange,Pancreatitis, biological redox systems, oxidative stress

submitter keyword: mouse model, cysteine, disulfide exchange,Pancreatitis, biological redox systems, oxidative stress

Contact List

Antonio Martínez-Ruiz
contact affiliation	Unidad de Investigación, Hospital Santa Cristina, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain
contact email	amartinezruiz@salud.madrid.org
lab head
Antonio Martínez Ruiz
contact affiliation	Instituto de Investigacion Sanitaria Princesa (IIS-IP)
contact email	amartinezruiz@salud.madrid.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD050765
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD050765

PRIDE project URI

Repository Record List

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