PXD050744

PXD050744 is an original dataset announced via ProteomeXchange.

Title	PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featuring with enhanced adaptive immunosuppression
Description	Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molecules carried on circulating small extracellular vesicles (sEV) might contribute to the low response rate. Here we demonstrate that PD-1 and CD80 carried on immunocyte-derived sEVs (I-sEV) induce an adaptive redistribution of PD-L1 in tumour cells. The resulting decreased cell membrane PD-L1 expression and increased sEV PD-L1 secretion into the circulation contribute to systemic immunosuppression. PD-1/CD80+ I-sEVs also induce downregulation of adhesion- and antigen presentation-related molecules on tumour cells and impaired immune cell infiltration, thereby converting tumours to an immunologically cold phenotype. Moreover, synchronous analysis of multiple checkpoint molecules, including PD-1, CD80 and PD-L1, on circulating sEVs distinguishes clinical responders from those patients who poorly respond to anti-PD-1 treatment. Altogether, our study shows that sEVs carry multiple inhibitory immune checkpoints proteins, which form a potentially targetable adaptive loop to suppress antitumour immunity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:46:24.562.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kong-Huai Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-18 17:29:47	ID requested
1	2024-06-22 08:26:51	announced
⏵ 2	2024-10-22 06:46:25	announced	2024-10-22: Updated project metadata.

10.1038/s41467-024-48200-9;

Zhang LZ, Yang JG, Chen GL, Xie QH, Fu QY, Xia HF, Li YC, Huang J, Li Y, Wu M, Liu HM, Wang FB, Yi KZ, Jiang HG, Zhou FX, Wang W, Yu ZL, Zhang W, Zhong YH, Bian Z, Yang HY, Liu B, Chen G, small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression. Nat Commun, 15(1):3884(2024) [pubmed]

submitter keyword: Small extracellular vesicle

Immunosuppression

PD-1/CD80

Cold tumour

Lin-Zhou Zhang
contact affiliation	Wuhan University
contact email	Zhanglinzhou@whu.edu.cn
lab head
Kong-Huai Wang
contact affiliation	Wuhan University
contact email	wangkh1003@whu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD050744

PRIDE project URI

• PRIDE
  1. PXD050744
     1. Label: PRIDE project
     2. Name: PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featuring with enhanced adaptive immunosuppression