PXD050694

PXD050694 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic characterization of the molecular signature of congenital myopathies
Description	Congenital myopathies (CMs) are progressive diseases that constitute a diverse group of hereditary neuromuscular disorders that have been studied due to their diagnostic and therapeutic complexity. Due to the great clinical and molecular heterogeneity of CMs, this set of diseases constantly challenges healthcare teams and researchers pushing the multidisciplinary teams to better characterize biomarkers for more efficient diagnostic, enrichment of clinical trials design and therapeutic strategies. In this work we propose to characterize the molecular signature of nemaline, central core, multiminicore and fiber type disproportion myopathies as well as Duchenne and Becker dystrophy using a label free Mass Spectrometry NANOLC-MS/MS proteomic approach.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_13:31:56.210.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Unit
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-17 12:47:35	ID requested
⏵ 1	2025-05-06 13:31:57	announced

Publication List

da Silva JCT, Nogueira MRA, da Silva YM, Nogueira FCS, Canedo NHS, Carneiro K, de Abreu Pereira D, Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins. Sci Rep, 15(1):3293(2025) [pubmed]
10.1038/s41598-025-87995-5;

da Silva JCT, Nogueira MRA, da Silva YM, Nogueira FCS, Canedo NHS, Carneiro K, de Abreu Pereira D, Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins. Sci Rep, 15(1):3293(2025) [pubmed]

10.1038/s41598-025-87995-5;

Keyword List

submitter keyword: proteomics, Becker muscular dystrophy, Duchenne muscular dystrophy,mass spectrometry, biomarkers

submitter keyword: proteomics, Becker muscular dystrophy, Duchenne muscular dystrophy,mass spectrometry, biomarkers

Contact List

Fábio César Sousa Nogueira
contact affiliation	Unidade Proteômica, Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro; Laboratório de Proteômica (LabProt), LADETEC, Instituto de Química, Universidade Federal do Rio de Janeiro; Centro de Pesquisa em Medicina de Precisão, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro
contact email	fabiocsn@gmail.com
lab head
Proteomics Unit
contact affiliation	UFRJ
contact email	unidadeproteomica@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050694
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050694

PRIDE project URI

Repository Record List

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