PXD050639
PXD050639 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nuclear HMGB1 is critical for CD8 T cell IFN-g production and anti-tumor immunity |
| Description | HMGB1 has been extensively studied as a DAMP, with secreted cytokine function. However, its regulation on T cells, especially the function in the nucleus, has not been elucidated. Here, we extracted the total protein of CD8 T cells and enriched the proteins bound to HMGB1 through IP experiment. We found several proteins binding with HMGB1, which suggested that nuclear HMGB1 might regulate the function of CD8 T cells by interacting with these proteins. In our study, we focused on the binding of HMGB1 and Eomes, and found that HMGB1 supported the expression of IFN-g in CD8 T cells by directly regulating the activity of the transcription factor Eomes of IFN-g. In conclusion, we determined the role of nuclear HMGB1 in the differentiation of CD8 T cells and proved that it played an important role in the anti-tumor program of CD8 T cells. |
| HostingRepository | iProX |
| AnnounceDate | 2024-03-15 |
| AnnouncementXML | Submission_2024-10-11_23:53:27.347.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiguang Xu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-03-14 23:22:36 | ID requested | |
| 1 | 2024-03-14 23:23:35 | announced | |
| ⏵ 2 | 2024-10-11 23:53:28 | announced | 2024-10-12: Update information. |
Publication List
| Xu Z, Ma W, Wang J, Chen H, Li H, Yin Z, Hao J, Chen K, production and anti-tumor immunity. Cell Rep, 43(8):114591(2024) [pubmed] |
Keyword List
| submitter keyword: HMGB1, CD8 T cell, Eomes, Tumor, IFN-g |
Contact List
| Kebing Chen | |
|---|---|
| contact affiliation | The Sixth Affiliated Hospital of Sun Yat-sen University |
| contact email | chkbing@mail.sysu.edu.cn |
| lab head | |
| Zhiguang Xu | |
| contact affiliation | The Sixth Affiliated Hospital of Sun Yat-sen University |
| contact email | 1309151665@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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