PXD050623 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Novel epigenetic based differentiation therapy for Acute Myeloid Leukemia |
Description | We have identified and characterized two lysine (K) deacetylase inhibitors (DACi), CM-444 and CM-1758. These inhibitors demonstrate the ability to promote myeloid differentiation in all acute myeloid leukemia (AML) subtypes at low, non-cytotoxic doses, setting them apart from other commercially available histone deacetylase inhibitors (HDACi). Upon analysis of the acetylome following treatment with CM-444 and CM-1758, we observed modulation of non-histone proteins involved in the enhancer–promoter chromatin regulatory complex, including bromodomain proteins (BRDs). This acetylation is crucial for enhancing the expression of key transcription factors directly involved in the differentiation therapy induced by CM-444 and CM-1758 in AML. In summary, these compounds present promising potential as effective differentiation-based therapeutic agents across AML subtypes, offering a novel mechanism for the treatment of AML |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-03 |
AnnouncementXML | Submission_2024-06-03_06:06:38.779.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fernando Garcia |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-14 09:40:33 | ID requested | |
⏵ 1 | 2024-06-03 06:06:39 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: acetylome, bromodomains, DACi, epigenetics, non-histone proteins acetylation,Acute myeloid leukemia, differentiation-based therapy |
Contact List
Fernando Garcia Martinez |
contact affiliation | Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112 |
contact email | fgarcia@cnio.es |
lab head | |
Fernando Garcia |
contact affiliation | Fernando García Martínez, Ph.D. Proteomics Unit, Spanish National cancer Research Center, CNIO, MADRID, SPAIN |
contact email | fgarcia@cnio.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050623
- Label: PRIDE project
- Name: Novel epigenetic based differentiation therapy for Acute Myeloid Leukemia