PXD050610

PXD050610 is an original dataset announced via ProteomeXchange.

Title	The Human Cardiac “Age-OME”: Age-specific changes in myocardial molecular
Description	Ageing is one of the most significant risk factors for heart disease, however, it is still not clear how the human heart changes with age. Taking advantage of a unique set of pre-mortem, cryopreserved, non-diseased human hearts, we performed omics analyses (transcriptomics, proteomics, metabolomics, and lipidomics), coupled with biologically-informed computational modelling in younger (≤25 years old) and older hearts (≥50 years old) to describe the molecular landscape of human cardiac ageing. In older hearts, we observed a downregulation of proteins involved in calcium signalling and contractile apparatus. Furthermore, we found a potential dysregulation of central carbon generation of fuel, glycolysis and fatty acids oxidation, along with an increase in long-chain fatty acids. This study presents and analyses the first molecular data set of normal human cardiac ageing, which has relevant implications for understanding the human cardiac ageing process and the development of age-related heart disease.
HostingRepository	PRIDE
AnnounceDate	2025-11-17
AnnouncementXML	Submission_2025-11-16_18:04:42.133.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mark Larance
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-14 01:14:43	ID requested
⏵ 1	2025-11-16 18:04:46	announced

10.1111/acel.70219;

Malecki C, Guglielmi G, Hunter B, Harney D, Koay YC, Don AS, Han O, Khor J, Nguyen L, Pan M, Gawthrop P, Isles N, Chung J, Hume RD, Taper M, Wang X, Larance M, Spill F, Rajagopal V, O'Sullivan JF, Lal S, The Human Cardiac "Age-OME": Age-Specific Changes in Myocardial Molecular Expression. Aging Cell, 24(11):e70219(2025) [pubmed]

submitter keyword: Human, metabolism, heart, aging, Excitation-Contraction Coupling

Mark Larance
contact affiliation	School of Medical Sciences, Faculty of Medicine and Healthy, University of Sydney, Sydney, Australia.
contact email	mark.larance@sydney.edu.au
lab head
Mark Larance
contact affiliation	The University of Sydney
contact email	mark.larance@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD050610

PRIDE project URI

• PRIDE
  1. PXD050610
     1. Label: PRIDE project
     2. Name: The Human Cardiac “Age-OME”: Age-specific changes in myocardial molecular