PXD050597

PXD050597 is an original dataset announced via ProteomeXchange.

Title	Dental calculus formation rate: the role of salivary proteome and metaproteome
Description	This study investigated the differences in saliva composition between individuals with rapid and slow dental calculus formation rates. A total of 26 patients were evaluated for their salivary electrochemical properties, and proteomic, metaproteomic, and elemental compositions. After dental cleaning and a six-month reassessment, patients were categorized into slow (57.7%) and rapid (42.3%) calculus formers. Results indicated that rapid formers had a more neutral zeta-potential, lower salivary calcium ion concentration, distinct protein profiles including 38 exclusive proteins, and pathways related to cell binding, inflammatory mediation, and neurodegenerative disorders. In contrast, slow formers showed an immune response enrichment and a different bacterial composition, with a predominance of Streptococci in rapid formers and Rothia in slow formers. The study concludes that rapid calculus formers' saliva significantly differs in several key compositions from slow formers.
HostingRepository	PRIDE
AnnounceDate	2024-09-04
AnnouncementXML	Submission_2024-09-04_05:35:46.609.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenji Cai
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-13 12:59:19	ID requested
⏵ 1	2024-09-04 05:35:46	announced

Dataset with its publication pending

submitter keyword: dental calculus, proteomics, salivary proteome, metaproteome, human saliva, zeta potential

Faleh Tamimi
contact affiliation	McGill University-Faculty of Dentistry 3640 University Street, Room M64, Montreal, QC Canada, H3A 0C7
contact email	faleh.tamimimarino@mcgill.ca
lab head
Wenji Cai
contact affiliation	McGill University
contact email	wenji.cai@mail.mcgill.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD050597

PRIDE project URI

• PRIDE
  1. PXD050597
     1. Label: PRIDE project
     2. Name: Dental calculus formation rate: the role of salivary proteome and metaproteome