PXD050591

PXD050591 is an original dataset announced via ProteomeXchange.

Title	Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase
Description	Butyrate has been proposed as a drug therapy by acting as a lysine deacetylase (KDAC) inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues such as the gut can utilize butyrate as a metabolite. We have previously shown that the addition of butyrate induces a rapid increase of oxygen consumption in whole Drosophila melanogaster heads. Here we show that while head oxygen consumption is increased by the addition of butyrate, no apparent changes are observed on the proteome and acetylome. Instead, we show that butyrate is metabolized and incorporated into the tricarboxylic acid (TCA) cycle. Collectively our data supports the notion that the therapeutic benefits of acute butyrate treatment may be also mediated by improving metabolic rates, rather than solely targeting the epigenome or acetylome.
HostingRepository	PRIDE
AnnounceDate	2025-01-16
AnnouncementXML	Submission_2025-01-16_01:05:47.132.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christina Ludwig
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-13 09:40:04	ID requested
⏵ 1	2025-01-16 01:05:47	announced

10.1371/journal.pone.0315892;

M, ü, ller-Eigner A, Gille B, Dethloff F, Meng C, Ludwig C, Heiker JT, Giavalisco P, Peleg S, Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. PLoS One, 19(12):e0315892(2024) [pubmed]

submitter keyword: oxygen consumption, Drosophila,Butyrate

Christina Ludwig
contact affiliation	Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) Technical University Munich Gregor-Mendel-Straße 4 85354 Freising
contact email	tina.ludwig@tum.de
lab head
Christina Ludwig
contact affiliation	TU Munich
contact email	tina.ludwig@tum.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050591
     1. Label: PRIDE project
     2. Name: Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase