PXD050577

PXD050577 is an original dataset announced via ProteomeXchange.

Title	Risk stratification of thyroid papillary cancer based on proteomics and machine learning
Description	Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma accounting for 85%. Most PTCs have a low risk of recurrence and metastasizing and not all low-risk PTCs need immediate surgery. However, cases are often recognized as low-risk only after surgery. Our study aimed to find a preoperative stratification strategy to distinguish low- from intermediate- and higher-risk cases to avoid unnecessary thyroidectomies or delayed surgeries. We conducted a retrospective, multicenter study with 558 PTCs comprising 118 pre- (n=118) and post- (n=440) operative samples. PTC samples were classified into high-, intermediate-, or low-risk according to the traditional postoperative assessment. From each patient, we collected clinical information, immunological indices, and BRAFV600E mutation assessment. Proteomic profiling was conducted through data-independent acquisition mode by mass spectrometry.
HostingRepository	iProX
AnnounceDate	2024-03-13
AnnouncementXML	Submission_2024-03-12_23:59:05.105.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuanhui Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-12 23:55:20	ID requested
⏵ 1	2024-03-12 23:59:05	announced

Li Y, Wu F, Ge W, Zhang Y, Hu Y, Zhao L, Gou W, Shi J, Ni Y, Li L, Fu W, Lin X, Yu Y, Han Z, Chen C, Xu R, Zhang S, Zhou L, Pan G, Peng Y, Mao L, Zhou T, Zheng J, Zheng H, Sun Y, Guo T, Luo D, Risk stratification of papillary thyroid cancers using multidimensional machine learning. Int J Surg, 110(1):372-384(2024) [pubmed]

submitter keyword: Papillary thyroid carcinoma, machine learning, risk stratification

Tiannan Guo
contact affiliation	Westlake University
contact email	guotiannan@westlake.edu.cn
lab head
Yuanhui Li
contact affiliation	Affiliated Hangzhou First People’s Hospital
contact email	liyuanhui@zju.edu.cn
dataset submitter

iProX dataset URI