PXD050571
PXD050571 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding |
Description | Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the founding members of the DEAD-box RNA helicase family, was dramatically downregulated in the degenerated articular cartilage of aged mice, destabilization of the medial meniscus murine model as well as patients with OA. Our data suggest that strategies aimed at upregulation of DDX5 will be of great value for the treatment of cartilage fibrosis and damage in OA. |
HostingRepository | iProX |
AnnounceDate | 2024-03-13 |
AnnouncementXML | Submission_2024-10-17_20:25:30.011.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Linhui Zhai |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-12 22:06:50 | ID requested | |
1 | 2024-03-12 22:08:30 | announced | |
⏵ 2 | 2024-10-17 20:25:30 | announced | 2024-10-18: Update information. |
Publication List
Liu Q, Han M, Wu Z, Fu W, Ji J, Liang Q, Tan M, Zhai L, Gao J, Shi D, Jiang Q, Sun Z, Lai Y, Xu Q, Sun Y, DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding. Nat Aging, 4(5):664-680(2024) [pubmed] |
Keyword List
submitter keyword: DDX5, COL2, COL1, alternative splicing, G-quadruplex, osteoarthritis |
Contact List
Minjia Tan | |
---|---|
contact affiliation | Shanghai Institute of Materia Medica |
contact email | mjtan@simm.ac.cn |
lab head | |
Linhui Zhai | |
contact affiliation | Shanghai Institute of Materia Medica |
contact email | zhailinhui@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |