PXD050569
PXD050569 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mass-spectroscopic quantification of CHAC1-regulated protein cysteine S-glutathionylation |
Description | S-glutathionylation is an important post-translational modification of a cysteine residue of target protein. We applied a quantitative redox proteomics approach to identify the specific cysteine residues as targets of S-glutathionylation. Using this approach, we profiled CHAC1-associated changes in glutathionylome in APAP-induced hepatoxicity and ferroptosis. Primary mouse hepatocytes (PMHs) were infected with Ad-GFP or Ad-CHAC1 for 36 h, and then challenged with 20 mM APAP for 3 h followed by the enrichment and quantitative analysis of glutathionylated proteins. |
HostingRepository | iProX |
AnnounceDate | 2024-03-12 |
AnnouncementXML | Submission_2025-03-31_19:43:14.379.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xiaobo Li |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-12 22:00:30 | ID requested | |
⏵ 1 | 2025-03-31 19:43:14 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: S-glutathionylation |
CHAC1 |
ferroptosis |
acetaminophen |
hepatocytes |
Contact List
Xiaobo Li | |
---|---|
contact affiliation | Fudan University |
contact email | xbli@fudan.edu.cn |
lab head | |
Xiaobo Li | |
contact affiliation | Fudan University |
contact email | xbli@fudan.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |