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PXD050569

PXD050569 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMass-spectroscopic quantification of CHAC1-regulated protein cysteine S-glutathionylation
DescriptionS-glutathionylation is an important post-translational modification of a cysteine residue of target protein. We applied a quantitative redox proteomics approach to identify the specific cysteine residues as targets of S-glutathionylation. Using this approach, we profiled CHAC1-associated changes in glutathionylome in APAP-induced hepatoxicity and ferroptosis. Primary mouse hepatocytes (PMHs) were infected with Ad-GFP or Ad-CHAC1 for 36 h, and then challenged with 20 mM APAP for 3 h followed by the enrichment and quantitative analysis of glutathionylated proteins.
HostingRepositoryiProX
AnnounceDate2024-03-12
AnnouncementXMLSubmission_2025-03-31_19:43:14.379.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXiaobo Li
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-12 22:00:30ID requested
12025-03-31 19:43:14announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: S-glutathionylation
CHAC1
ferroptosis
acetaminophen
hepatocytes
Contact List
Xiaobo Li
contact affiliationFudan University
contact emailxbli@fudan.edu.cn
lab head
Xiaobo Li
contact affiliationFudan University
contact emailxbli@fudan.edu.cn
dataset submitter
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iProX dataset URI