PXD050542

PXD050542 is an original dataset announced via ProteomeXchange.

Title	Proteomic data of human nasopharyngeal carcinoma cells
Description	LVTX-8, a peptide toxin synthesized from the cDNA library of the spider Lycosa vittata with 25 amino acids. In this study, we performed a series of cellular and molecular experiments such as cell toxicity, colony formation, and cell migration assays to exam the anticancer activity, selectivity and evaluate the cell toxicity of LVTX-8 in NPC cells (5-8F and CNE-2). The results suggested that LVTX-8 significantly inhibited cell proliferation and migration in both cell lines. To find the potential drug targets and further explain the molecular mechanisms underlying the anticancer capability of LVTX-8, high throughput proteomics profiling were performed.
HostingRepository	iProX
AnnounceDate	2024-03-11
AnnouncementXML	Submission_2024-05-08_23:38:06.138.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Siyuan Xu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-11 19:20:49	ID requested
1	2024-03-11 19:21:21	announced
⏵ 2	2024-05-08 23:38:07	announced	2024-05-09: Update information.

Zhu G, Wang L, Wang X, Dong X, Yang S, Wang J, Xu S, Zeng Y, Comparative Proteomics Identified EXOSC1 as a Target Protein of Anticancer Peptide LVTX-8 in Nasopharyngeal Carcinoma Cells. J Proteome Res, 23(6):2028-2040(2024) [pubmed]

submitter keyword: nasopharyngeal carcinoma, LVTX-8, proteomics

Yong Zeng
contact affiliation	Hunan Normal University
contact email	yongz@hunnu.edu.cn
lab head
Siyuan Xu
contact affiliation	Hunan Normal University
contact email	xusiyuan@hunnu.edu.cn
dataset submitter

iProX dataset URI