PXD050542
PXD050542 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic data of human nasopharyngeal carcinoma cells |
Description | LVTX-8, a peptide toxin synthesized from the cDNA library of the spider Lycosa vittata with 25 amino acids. In this study, we performed a series of cellular and molecular experiments such as cell toxicity, colony formation, and cell migration assays to exam the anticancer activity, selectivity and evaluate the cell toxicity of LVTX-8 in NPC cells (5-8F and CNE-2). The results suggested that LVTX-8 significantly inhibited cell proliferation and migration in both cell lines. To find the potential drug targets and further explain the molecular mechanisms underlying the anticancer capability of LVTX-8, high throughput proteomics profiling were performed. |
HostingRepository | iProX |
AnnounceDate | 2024-03-11 |
AnnouncementXML | Submission_2024-05-08_23:38:06.138.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Siyuan Xu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-11 19:20:49 | ID requested | |
1 | 2024-03-11 19:21:21 | announced | |
⏵ 2 | 2024-05-08 23:38:07 | announced | 2024-05-09: Update information. |
Publication List
Zhu G, Wang L, Wang X, Dong X, Yang S, Wang J, Xu S, Zeng Y, Comparative Proteomics Identified EXOSC1 as a Target Protein of Anticancer Peptide LVTX-8 in Nasopharyngeal Carcinoma Cells. J Proteome Res, 23(6):2028-2040(2024) [pubmed] |
Keyword List
submitter keyword: nasopharyngeal carcinoma, LVTX-8, proteomics |
Contact List
Yong Zeng | |
---|---|
contact affiliation | Hunan Normal University |
contact email | yongz@hunnu.edu.cn |
lab head | |
Siyuan Xu | |
contact affiliation | Hunan Normal University |
contact email | xusiyuan@hunnu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |