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PXD050542

PXD050542 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic data of human nasopharyngeal carcinoma cells
DescriptionLVTX-8, a peptide toxin synthesized from the cDNA library of the spider Lycosa vittata with 25 amino acids. In this study, we performed a series of cellular and molecular experiments such as cell toxicity, colony formation, and cell migration assays to exam the anticancer activity, selectivity and evaluate the cell toxicity of LVTX-8 in NPC cells (5-8F and CNE-2). The results suggested that LVTX-8 significantly inhibited cell proliferation and migration in both cell lines. To find the potential drug targets and further explain the molecular mechanisms underlying the anticancer capability of LVTX-8, high throughput proteomics profiling were performed.
HostingRepositoryiProX
AnnounceDate2024-03-11
AnnouncementXMLSubmission_2024-05-08_23:38:06.138.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSiyuan Xu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-11 19:20:49ID requested
12024-03-11 19:21:21announced
22024-05-08 23:38:07announced2024-05-09: Update information.
Publication List
Zhu G, Wang L, Wang X, Dong X, Yang S, Wang J, Xu S, Zeng Y, Comparative Proteomics Identified EXOSC1 as a Target Protein of Anticancer Peptide LVTX-8 in Nasopharyngeal Carcinoma Cells. J Proteome Res, 23(6):2028-2040(2024) [pubmed]
Keyword List
submitter keyword: nasopharyngeal carcinoma, LVTX-8, proteomics
Contact List
Yong Zeng
contact affiliationHunan Normal University
contact emailyongz@hunnu.edu.cn
lab head
Siyuan Xu
contact affiliationHunan Normal University
contact emailxusiyuan@hunnu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI