PXD050505
PXD050505 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Insights into the role of de novo fatty acid synthesis in IL-17-producing γδ T cells upon psoriatic inflammation |
Description | γδ T cells produce the primary innate source of IL-17 (γδT17) and are known to play a critical role in autoimmune and inflammatory diseases such as psoriasis. We here reported that psoriatic condition (IL-1b and IL-23) reshaped metabolic signatures and effector function of γδT17 cells compared to homeostatic condition (IL-7). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs the fate of IL-17-producing CD4 T cells (Th17) differentiation. However, little is known about the role of ACC1-mediated FAS in their innate IL-17-producer counterpart, γδT17 cells. We further investigated the role of FAS in γδT17 by comparing the effect of pharmacological ACC inhibitor Soraphen A (SorA) on DMSO vehicle under psoriatic conditions (IL-1b and IL-23) to provide insights for clinical implication. |
HostingRepository | jPOST |
AnnounceDate | 2025-02-20 |
AnnouncementXML | Submission_2025-02-20_11:00:27.018.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ute Distler |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide |
Instrument | instrument |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-10 06:53:58 | ID requested | |
⏵ 1 | 2025-02-20 11:00:27 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: IL-17-producing γδ T cells, fatty acid synthesis, proteome analysis, label-free |
Contact List
Prof. Dr. Tim Sparwasser | |
---|---|
lab head | |
Ute Distler | |
contact affiliation | University Medical Center Mainz |
dataset submitter |
Full Dataset Link List
jPOST dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002976/ |