PXD050505

PXD050505 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Insights into the role of de novo fatty acid synthesis in IL-17-producing γδ T cells upon psoriatic inflammation
Description	γδ T cells produce the primary innate source of IL-17 (γδT17) and are known to play a critical role in autoimmune and inflammatory diseases such as psoriasis. We here reported that psoriatic condition (IL-1b and IL-23) reshaped metabolic signatures and effector function of γδT17 cells compared to homeostatic condition (IL-7). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs the fate of IL-17-producing CD4 T cells (Th17) differentiation. However, little is known about the role of ACC1-mediated FAS in their innate IL-17-producer counterpart, γδT17 cells. We further investigated the role of FAS in γδT17 by comparing the effect of pharmacological ACC inhibitor Soraphen A (SorA) on DMSO vehicle under psoriatic conditions (IL-1b and IL-23) to provide insights for clinical implication.
HostingRepository	jPOST
AnnounceDate	2025-02-20
AnnouncementXML	Submission_2025-02-20_11:00:27.018.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ute Distler
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-10 06:53:58	ID requested
⏵ 1	2025-02-20 11:00:27	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: IL-17-producing γδ T cells, fatty acid synthesis, proteome analysis, label-free

submitter keyword: IL-17-producing γδ T cells, fatty acid synthesis, proteome analysis, label-free

Contact List

Prof. Dr. Tim Sparwasser
lab head
Ute Distler
contact affiliation	University Medical Center Mainz
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002976/