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PXD050505

PXD050505 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInsights into the role of de novo fatty acid synthesis in IL-17-producing γδ T cells upon psoriatic inflammation
Descriptionγδ T cells produce the primary innate source of IL-17 (γδT17) and are known to play a critical role in autoimmune and inflammatory diseases such as psoriasis. We here reported that psoriatic condition (IL-1b and IL-23) reshaped metabolic signatures and effector function of γδT17 cells compared to homeostatic condition (IL-7). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs the fate of IL-17-producing CD4 T cells (Th17) differentiation. However, little is known about the role of ACC1-mediated FAS in their innate IL-17-producer counterpart, γδT17 cells. We further investigated the role of FAS in γδT17 by comparing the effect of pharmacological ACC inhibitor Soraphen A (SorA) on DMSO vehicle under psoriatic conditions (IL-1b and IL-23) to provide insights for clinical implication.
HostingRepositoryjPOST
AnnounceDate2025-02-20
AnnouncementXMLSubmission_2025-02-20_11:00:27.018.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterUte Distler
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListS-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-10 06:53:58ID requested
12025-02-20 11:00:27announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: IL-17-producing γδ T cells, fatty acid synthesis, proteome analysis, label-free
Contact List
Prof. Dr. Tim Sparwasser
lab head
Ute Distler
contact affiliationUniversity Medical Center Mainz
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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