PXD050501

PXD050501 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	To characterize the DMTF1 proximity proteome using BioID-mass spectrometry analysis
Description	Neural stem cells (NSCs) contribute to brain development and homeostasis via their unique properties of self-renewal and differentiation. DMTF1 is a transcription factor that is proposed to be a tumor suppressor in cancer cells. However, the exact role of DMTF1 in NSC biology remains poorly understood. We found that DMTF1 depletion reduced the proliferation/self-renewal of mouse and human NSCs in vitro. To elucidate how DMTF1 may regulate gene transcription along with other proteins, we have employed BioID-mass spectrometry analysis of DMTF1 vs GFP proximity proteomes in 293T cells. The identified candidate DMTF1 protein interactors will subsequently be validated in mouse NSC. This study aims to investigate how DMTF1 regulates NSC proliferation.
HostingRepository	jPOST
AnnounceDate	2025-03-10
AnnouncementXML	Submission_2025-03-09_08:00:08.717.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Radoslaw Sobota
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; alpha-amino acetylated residue; deamidated L-glutamine; deamidated L-asparagine
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-09 20:31:51	ID requested
⏵ 1	2025-03-09 08:00:09	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: DMTF1, NSC proliferation,

submitter keyword: DMTF1, NSC proliferation,

Contact List

Dr. Derrick ONG
lab head
Radoslaw Sobota
contact affiliation	IMCB A-STAR Singapore
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002968/