PXD050496

PXD050496 is an original dataset announced via ProteomeXchange.

Title	SERUM PROTEOMICS OF Experimental MALARIA-associated ARDS REVEALS A REGULATION OF ACUTE PHASE RESPONSE PROTEINS
Description	Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injuries pathways have been determined through these studies, specific circulating malaria-associated ARDS markers have not yet been established. We applied a quantitative mass spectrometry-based proteomic approach to identify altered molecular pathways in a mouse model of malaria-associated ARDS. Acute phase response proteins were regulated in the ARDS group, suggesting potential progression biomarkers.
HostingRepository	PRIDE
AnnounceDate	2025-05-13
AnnouncementXML	Submission_2025-05-13_06:10:57.841.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simon Mule
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-09 14:20:59	ID requested
⏵ 1	2025-05-13 06:10:58	announced

10.1155/jimr/5642957;

Rosa-Fernandes L, Santiago VF, da Silva-Santos Y, Lopes TT, Peixoto EPM, Rodrigues SAM, Marinho CRF, Palmisano G, Epiphanio S, Serum Proteomics of Experimental Malaria-Associated ARDS Reveals a Regulation of Acute-Phase Response Proteins. J Immunol Res, 2025():5642957(2025) [pubmed]

submitter keyword: Biomarkers, Malaria, Acute resipratory distress syndrome, Proteomics

Prof. Dr. Giuseppe Palmisano
contact affiliation	Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, Brazil
contact email	palmisano.gp@usp.br
lab head
Simon Mule
contact affiliation	Universidade de São Paulo
contact email	ngaosimon@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050496

PRIDE project URI

• PRIDE
  1. PXD050496
     1. Label: PRIDE project
     2. Name: SERUM PROTEOMICS OF Experimental MALARIA-associated ARDS REVEALS A REGULATION OF ACUTE PHASE RESPONSE PROTEINS