PXD050494

PXD050494 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Coexistence of Klebsiella pneumonia biofilms with Candida albicans in an acute pneumonia
Description	Coexistence of polymicrobial organisms acted as biofilm communities has become more and more prominent that these interactions lead to an increased resistance against host immune responses and antimicrobial agents, especially bacterial-fungal interactions. Klebsiella pneumoniae and Candida albicans are one of the interesting candidates acted as interkingdom biofilms. K. pneumoniae and C. albicans (KP+CA) presented the interkingdom biofilms with synergistic interaction through molecular analysis and confocal fluorescent imaging with z-stack thickness in vitro experiments. Both of an acute pneumonia model and in vitro neutrophil responses demonstrated that K. pneumoniae infection performed the highest severity when compared to mixed K. pneumoniae and C. albicans and alone C. albicans infections through various biomarkers and the responsiveness of neutrophils. Consequently, this study indicated that polymicrobial with bacterial-Candida infection may less severe than single-bacterial infection.
HostingRepository	PRIDE
AnnounceDate	2025-05-13
AnnouncementXML	Submission_2025-05-13_06:23:15.392.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiradej Makjaroen
SpeciesList	scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-09 05:35:26	ID requested
⏵ 1	2025-05-13 06:23:16	announced

Publication List

Phuengmaung P, Chongrak C, Saisorn W, Makjaroen J, Singkham-In U, Leelahavanichkul A, Alone. Int J Mol Sci, 25(22):(2024) [pubmed]
10.3390/ijms252212157;

Phuengmaung P, Chongrak C, Saisorn W, Makjaroen J, Singkham-In U, Leelahavanichkul A, Alone. Int J Mol Sci, 25(22):(2024) [pubmed]

10.3390/ijms252212157;

Keyword List

submitter keyword: Klebsiella pneumonia, Pneumonia, Biofilm formation, Candida albicans, Neutrophil extracellular traps

submitter keyword: Klebsiella pneumonia, Pneumonia, Biofilm formation, Candida albicans, Neutrophil extracellular traps

Contact List

Assoc.Prof.Asada Leelahavanichkul
contact affiliation	Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,
contact email	aleelahavanit@gmail.com
lab head
Jiradej Makjaroen
contact affiliation	Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330
contact email	jiradejmak@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050494
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050494

PRIDE project URI

Repository Record List

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