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PXD050494

PXD050494 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCoexistence of Klebsiella pneumonia biofilms with Candida albicans in an acute pneumonia
DescriptionCoexistence of polymicrobial organisms acted as biofilm communities has become more and more prominent that these interactions lead to an increased resistance against host immune responses and antimicrobial agents, especially bacterial-fungal interactions. Klebsiella pneumoniae and Candida albicans are one of the interesting candidates acted as interkingdom biofilms. K. pneumoniae and C. albicans (KP+CA) presented the interkingdom biofilms with synergistic interaction through molecular analysis and confocal fluorescent imaging with z-stack thickness in vitro experiments. Both of an acute pneumonia model and in vitro neutrophil responses demonstrated that K. pneumoniae infection performed the highest severity when compared to mixed K. pneumoniae and C. albicans and alone C. albicans infections through various biomarkers and the responsiveness of neutrophils. Consequently, this study indicated that polymicrobial with bacterial-Candida infection may less severe than single-bacterial infection.
HostingRepositoryPRIDE
AnnounceDate2025-05-13
AnnouncementXMLSubmission_2025-05-13_06:23:15.392.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiradej Makjaroen
SpeciesList scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-09 05:35:26ID requested
12025-05-13 06:23:16announced
Publication List
Phuengmaung P, Chongrak C, Saisorn W, Makjaroen J, Singkham-In U, Leelahavanichkul A, Alone. Int J Mol Sci, 25(22):(2024) [pubmed]
10.3390/ijms252212157;
Keyword List
submitter keyword: Klebsiella pneumonia, Pneumonia, Biofilm formation, Candida albicans, Neutrophil extracellular traps
Contact List
Assoc.Prof.Asada Leelahavanichkul
contact affiliationDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,
contact emailaleelahavanit@gmail.com
lab head
Jiradej Makjaroen
contact affiliationCenter of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330
contact emailjiradejmak@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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