PXD050494 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Coexistence of Klebsiella pneumonia biofilms with Candida albicans in an acute pneumonia |
Description | Coexistence of polymicrobial organisms acted as biofilm communities has become more and more prominent that these interactions lead to an increased resistance against host immune responses and antimicrobial agents, especially bacterial-fungal interactions. Klebsiella pneumoniae and Candida albicans are one of the interesting candidates acted as interkingdom biofilms. K. pneumoniae and C. albicans (KP+CA) presented the interkingdom biofilms with synergistic interaction through molecular analysis and confocal fluorescent imaging with z-stack thickness in vitro experiments. Both of an acute pneumonia model and in vitro neutrophil responses demonstrated that K. pneumoniae infection performed the highest severity when compared to mixed K. pneumoniae and C. albicans and alone C. albicans infections through various biomarkers and the responsiveness of neutrophils. Consequently, this study indicated that polymicrobial with bacterial-Candida infection may less severe than single-bacterial infection. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-13 |
AnnouncementXML | Submission_2025-05-13_06:23:15.392.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jiradej Makjaroen |
SpeciesList | scientific name: Candida albicans (Yeast); NCBI TaxID: 5476; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-09 05:35:26 | ID requested | |
⏵ 1 | 2025-05-13 06:23:16 | announced | |
Publication List
Phuengmaung P, Chongrak C, Saisorn W, Makjaroen J, Singkham-In U, Leelahavanichkul A, Alone. Int J Mol Sci, 25(22):(2024) [pubmed] |
10.3390/ijms252212157; |
Keyword List
submitter keyword: Klebsiella pneumonia, Pneumonia, Biofilm formation, Candida albicans, Neutrophil extracellular traps |
Contact List
Assoc.Prof.Asada Leelahavanichkul |
contact affiliation | Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, |
contact email | aleelahavanit@gmail.com |
lab head | |
Jiradej Makjaroen |
contact affiliation | Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330 |
contact email | jiradejmak@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050494 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050494
- Label: PRIDE project
- Name: Coexistence of Klebsiella pneumonia biofilms with Candida albicans in an acute pneumonia