PXD050491

PXD050491 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Glyceraldehyde treatment on pancreatic ductal epithelial cells
Description	To study the impact of the accumulation of glyceraldehyde-derived intracellular protein advanced glycation end products (AGEs) on global proteomic changes in pancreatic ductal epithelial cells. The cells were treated with glyceraldehyde for up to 2 days and changes of protein expressions were assessed through mass spectroscopic analysis.
HostingRepository	PRIDE
AnnounceDate	2025-07-21
AnnouncementXML	Submission_2025-07-20_16:18:58.221.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lakmini Senavirathna
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-08 12:58:52	ID requested
⏵ 1	2025-07-20 16:18:59	announced

Publication List

10.1021/acs.biochem.4c00250;
Senavirathna L, Hasapes C, Chen R, Pan S, Accumulation of Intracellular Protein Advanced Glycation End Products Alters Cellular Homeostasis for Protein Clearance in Pancreatic Ductal Epithelial Cells. Biochemistry, 63(14):1723-1729(2024) [pubmed]

10.1021/acs.biochem.4c00250;

Senavirathna L, Hasapes C, Chen R, Pan S, Accumulation of Intracellular Protein Advanced Glycation End Products Alters Cellular Homeostasis for Protein Clearance in Pancreatic Ductal Epithelial Cells. Biochemistry, 63(14):1723-1729(2024) [pubmed]

Keyword List

ProteomeXchange project tag: Protein Misfolding and Aggregation (B/D-HPP), Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Diabetes (B/D-HPP)
submitter keyword: Glycation, Glyceraldehyde,Advanced Glcation End products (AGEs), epethelial cells

ProteomeXchange project tag: Protein Misfolding and Aggregation (B/D-HPP), Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Diabetes (B/D-HPP)

submitter keyword: Glycation, Glyceraldehyde,Advanced Glcation End products (AGEs), epethelial cells

Contact List

Sheng Pan
contact affiliation	The University of Texas Health Science Center at Houston. Institute of Molecular Medicine, Houston, TX, USA
contact email	sheng.pan@uth.tmc.edu
lab head
Lakmini Senavirathna
contact affiliation	University of Texas Health Science Center at Houston
contact email	herath.lakmini.senavirathna@uth.tmc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD050491
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD050491

PRIDE project URI

Repository Record List

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