PXD050471

PXD050471 is an original dataset announced via ProteomeXchange.

Title	Aeromonas spp MTB Infection May Causally Link to Ulcerative Colitis
Description	Ulcerative colitis (UC) is an inflammatory bowel disease characterized by disruption of the epithelial barrier, and its etiology has long been enigmatic. We here observed a significant depletion of macrophages directly beneath the UC epithelial layer, and hypothesized that this depletion may be caused by a toxic bacteria. By screening fecal bacteria of UC patients, we identified the causative bacteria as Aeromonas spp MTB (macrophage-toxic bacteria), a novel variant of Aeromonas genus. The expressed aerolysin was preferentially toxic towards macrophages, and severs as a primary virulent factor. MTB efficiently colonized mice after pretreatment with DSS and antibiotics, and thereby induced UC-like colitis. Moreover, both aerolysin toxin and fecal MTB respectively distributed in UC colon tissue and stool with high frequency. We thus proposed that MTB infection was causally linked to ulcerative colitis. As aerolysin antibody mitigated the colitis phenotypes, our result also revealed an innovative therapeutic approach for UC.
HostingRepository	PRIDE
AnnounceDate	2026-03-17
AnnouncementXML	Submission_2026-03-17_16:08:40.139.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhihui Jiang
SpeciesList	scientific name: Aeromonas veronii bv. sobria; NCBI TaxID: NEWT:114517;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-07 21:16:20	ID requested
⏵ 1	2026-03-17 16:08:41	announced

10.1126/science.adz4712;

Jiang Z, Wang Y, Gong J, Chen X, Hang D, Chen C, Hong X, Zhang J, Qiu K, Liao Y, Li P, Wang H, Yang Z, Qiu T, Zhou Y, Chen Z, Zhou H, Shan X, Zhou N, Liu L, Feng F, Su F, Ma H, Liu Z, He W, Fang L, Xuan J, Gan Z, Gao X, Zhang J, Chen H, Wang F, Zhang X, Zhu M, variant that produces aerolysin promotes susceptibility to ulcerative colitis. Science, 390(6775):eadz4712(2025) [pubmed]

submitter keyword: None

Zhu minsheng
contact affiliation	State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China.
contact email	zhums@nju.edu.cn
lab head
Zhihui Jiang
contact affiliation	Nanjing University
contact email	jiangzhihui@smail.nju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD050471

PRIDE project URI

• PRIDE
  1. PXD050471
     1. Label: PRIDE project
     2. Name: Aeromonas spp MTB Infection May Causally Link to Ulcerative Colitis