PXD050447

PXD050447 is an original dataset announced via ProteomeXchange.

Title	LCMS-based plasma proteome analysis of heart failure patients with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) for biomarker identification and patient profiling
Description	Heart failure (HF) diagnosis is complicated by varied pathophysiology, nonspecific symptoms and underlying comorbidities. This patient heterogeneity makes accurate treatment challenging and, as a result, can lead to worse clinical outcomes and increased healthcare cost. Measuring the plasma concentrations of natriuretic peptides can assist HF diagnosis with only moderate specificity. Therefore, there is a need for better diagnostic biomarkers with a higher specificity to establish the identification of HF, as well as to characterize and sub-profile HF patients for better treatment. We performed liquid chromatography mass spectrometry (LC-MS) to analyze the plasma proteomes of 249 HFpEF patients and 250 HFrEF patients (BIOSTAT-CHF) versus a control cohort of 99 patients without heart failure (PREVEND study). We identify significant changes in the plasma proteomes of HF patients versus non-HF controls. We applied machine learning algorithms to the data to identify new biomarker candidates for diagnosing HF and validated our findings in an independent heart failure cohort. Furthermore, we performed clustering analysis on the plasma protein profiles of the patients in order to characterize differences in HF sub-populations.
HostingRepository	PRIDE
AnnounceDate	2026-08-26
AnnouncementXML	Submission_2026-08-26_14:58:45.342.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Annabelle Hoegl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-07 08:16:44	ID requested
⏵ 1	2026-08-26 14:58:45	announced

10.1093/ESCHF/XVAG189;

10.1093/eschf/xvag189;

submitter keyword: HFpEF

HFrEF, heart failure

LC-MS

proteomics

plasma

biomarker

Mads Grønborg
contact affiliation	Global Translation, Omics Technologies, Novo Nordisk A/S, Måløv, Denmark.
contact email	mdgr@novonordisk.com
lab head
Annabelle Hoegl
contact affiliation	Novo Nordisk A/S
contact email	yabh@novonordisk.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD050447

PRIDE project URI

• PRIDE
  1. PXD050447
     1. Label: PRIDE project
     2. Name: LCMS-based plasma proteome analysis of heart failure patients with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) for biomarker identification and patient profiling