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PXD050425

PXD050425 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFrontiers in Plasma Proteome Profiling Platforms: Innovations and Applications.
DescriptionBiomarkers play a crucial role in advancing precision medicine by enabling more targeted and individualized approaches to diagnosis and treatment. Various biofluids, including serum, plasma, cerebrospinal fluid (CSF), saliva, tears, pancreatic cyst fluids, and urine, have been identified as rich sources of potential biomarkers. In this study, our focus is on comparing workflows for plasma proteomic profiling to establish a methodology that is not only sensitive and reproducible but also applicable for large cohort studies in biomarker discovery. Our investigation revealed that the SeerProteographXT workflow outperforms other workflows in terms of plasma proteome depth, quantitative accuracy, and reproducibility while offering complete automation of sample preparation. Notably, SeerProteographXT demonstrates versatility by applying it to various types of biofluids. Additionally, the proteins quantified widely cover secretory proteins in peripheral blood, and the pathway analysis enriched with relevant components such as interleukins, tissue necrosis factors, chemokines, and B and T cell receptors provides valuable insights. These proteins, often challenging to quantify in complex biological samples, hold potential as early detection markers for various diseases, thereby contributing to the improvement of patient care quality.
HostingRepositoryPRIDE
AnnounceDate2024-07-03
AnnouncementXMLSubmission_2024-07-03_03:37:28.253.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRajesh Soni
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentBruker Daltonics timsTOF series
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-06 16:05:10ID requested
12024-07-03 03:37:29announced
Publication List
10.1186/s12014-024-09497-2;
Soni RK, Frontiers in plasma proteome profiling platforms: innovations and applications. Clin Proteomics, 21(1):43(2024) [pubmed]
Keyword List
submitter keyword: Biomarker, SP100 Instrument, Biofluids proteome profiling, PreOmics-iST, Seer Proteograph, timstofPro2, Secretome, Plasma proteome
Contact List
Rajesh Kumar Soni
contact affiliationProteomics and Macromolecular Crystallography Shared Resource, Columbia University Irving Medical Center, New York, US
contact emailrs3869@cumc.columbia.edu
lab head
Rajesh Soni
contact affiliationColumbia University Medical center
contact emailrs3869@cumc.columbia.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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