PXD050425
PXD050425 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Frontiers in Plasma Proteome Profiling Platforms: Innovations and Applications. |
Description | Biomarkers play a crucial role in advancing precision medicine by enabling more targeted and individualized approaches to diagnosis and treatment. Various biofluids, including serum, plasma, cerebrospinal fluid (CSF), saliva, tears, pancreatic cyst fluids, and urine, have been identified as rich sources of potential biomarkers. In this study, our focus is on comparing workflows for plasma proteomic profiling to establish a methodology that is not only sensitive and reproducible but also applicable for large cohort studies in biomarker discovery. Our investigation revealed that the SeerProteographXT workflow outperforms other workflows in terms of plasma proteome depth, quantitative accuracy, and reproducibility while offering complete automation of sample preparation. Notably, SeerProteographXT demonstrates versatility by applying it to various types of biofluids. Additionally, the proteins quantified widely cover secretory proteins in peripheral blood, and the pathway analysis enriched with relevant components such as interleukins, tissue necrosis factors, chemokines, and B and T cell receptors provides valuable insights. These proteins, often challenging to quantify in complex biological samples, hold potential as early detection markers for various diseases, thereby contributing to the improvement of patient care quality. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-03 |
AnnouncementXML | Submission_2024-07-03_03:37:28.253.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rajesh Soni |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Bruker Daltonics timsTOF series |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-06 16:05:10 | ID requested | |
⏵ 1 | 2024-07-03 03:37:29 | announced |
Publication List
10.1186/s12014-024-09497-2; |
Soni RK, Frontiers in plasma proteome profiling platforms: innovations and applications. Clin Proteomics, 21(1):43(2024) [pubmed] |
Keyword List
submitter keyword: Biomarker, SP100 Instrument, Biofluids proteome profiling, PreOmics-iST, Seer Proteograph, timstofPro2, Secretome, Plasma proteome |
Contact List
Rajesh Kumar Soni | |
---|---|
contact affiliation | Proteomics and Macromolecular Crystallography Shared Resource, Columbia University Irving Medical Center, New York, US |
contact email | rs3869@cumc.columbia.edu |
lab head | |
Rajesh Soni | |
contact affiliation | Columbia University Medical center |
contact email | rs3869@cumc.columbia.edu |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD050425 |
PRIDE project URI |
Repository Record List
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