PXD050412

PXD050412 is an original dataset announced via ProteomeXchange.

Title	The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: Quantitative shotgun proteomics at the portals of entry after single and co-infections
Description	To date, little is known about the proteomic changes at the portals of entry in rainbow trout after infection with the myxozoans, Myxobolus cerebralis, and Tetracapsuloides bryosalmonae the causative agents of whirling disease and proliferative kidney disease, respectively. Therefore, the aim of this study was to provide the first proteomic profiles of the host in the search for evasion strategies against single and coinfection with M. cerebralis and T. bryosalmonae. One group of fish was initially infected with M. cerebralis and another group with T. bryosalmonae. After 30 days, half of the fish in each group were co-infected with the other parasite. Using a quantitative proteomic approach, we investigated proteomic changes in the caudal fins and gills of rainbow trout before and after co-infection. In the caudal fins, 16 proteins were differentially regulated post exposure to M. cerebralis, whereas 27 proteins were differentially modulated in the gills of the infected rainbow trout post exposure to T. bryosalmonae. After co-infection, 4 proteins involved in parasite recognition and the regulation of host immune responses were differentially modulated between the groups in the caudal fin. In the gills, 11 proteins involved in parasite recognition and host immunity, including 4 myxozoan proteins predicted to be virulence factors, were differentially modulated. The results of this study increase our knowledge on rainbow trout co-infections by myxozoan parasites and rainbow trout immune responses against myxozoa at the portals of entry, supporting a better understanding of these host-parasite interactions.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:38:13.364.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mona Saleh
SpeciesList	scientific name: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri); NCBI TaxID: 8022; scientific name: Myxozoa; NCBI TaxID: 35581;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-06 11:06:36	ID requested
1	2024-05-06 07:20:30	announced
⏵ 2	2024-10-22 06:38:13	announced	2024-10-22: Updated project metadata.

10.3389/FCIMB.2024.1369615;

submitter keyword: Immunomodulation, Proliferative kidney disease, Proteome,Salmonids, Whirling Disease

Mona Saleh
contact affiliation	Division of Fish Health Department of Farm Animals and Veterinary Public Health University of Veterinary Medicine Vienna Veterinaerplatz 1 1210 Vienna Austria
contact email	mona.saleh@vetmeduni.ac.at
lab head
Mona Saleh
contact affiliation	University of Veterinary Medicine Vienna
contact email	mona.saleh@vetmeduni.ac.at
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050412
     1. Label: PRIDE project
     2. Name: The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: Quantitative shotgun proteomics at the portals of entry after single and co-infections