PXD050402 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The network response to Egf is tissue-specific |
Description | Epidermal growth factor receptor (Egfr)-driven signaling regulates fundamental homeostatic processes. Dysregulated signaling via Egfr is implicated in numerous disease pathologies and distinct Egfr-associated disease etiologies are known to be tissue-specific. The molecular basis of this tissue specificity remains poorly understood. Most studies of Egfr signaling to date have been performed in vitro or in tissue-specific mouse models of disease, which has limited insight into Egfr signaling patterns in healthy tissues. Here, we carried out integrated phosphoproteomic, proteomic, and transcriptomic analyses of signaling changes across various mouse tissues in response to short-term stimulation with the Egfr ligand Egf. We show how both baseline and Egf-stimulated signaling behaviors differ between tissues. Moreover, we propose how baseline phosphorylation and total protein levels may be associated with clinically relevant tissue-specific Egfr-associated phenotypes. Altogether, our analyses illustrate tissue-specific effects of Egf stimulation and highlight potential links between underlying tissue biology and Egfr signaling output. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-08 |
AnnouncementXML | Submission_2025-03-08_11:30:46.565.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joao Paulo |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetic acid derivatized residue |
Instrument | Orbitrap Eclipse; Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-06 05:54:26 | ID requested | |
⏵ 1 | 2025-03-08 11:30:46 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: proteomics, multi-omics, tissue specificity,Egf, MAPK, phosphoproteomics, Egfr |
Contact List
Kevin M. Haigis |
contact affiliation | Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Department of Cancer Biology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA. |
contact email | Kevin_Haigis@dfci.harvard.edu |
lab head | |
Joao Paulo |
contact affiliation | Harvard Medical School |
contact email | joao_paulo@post.harvard.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050402
- Label: PRIDE project
- Name: The network response to Egf is tissue-specific