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PXD050402

PXD050402 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe network response to Egf is tissue-specific
DescriptionEpidermal growth factor receptor (Egfr)-driven signaling regulates fundamental homeostatic processes. Dysregulated signaling via Egfr is implicated in numerous disease pathologies and distinct Egfr-associated disease etiologies are known to be tissue-specific. The molecular basis of this tissue specificity remains poorly understood. Most studies of Egfr signaling to date have been performed in vitro or in tissue-specific mouse models of disease, which has limited insight into Egfr signaling patterns in healthy tissues. Here, we carried out integrated phosphoproteomic, proteomic, and transcriptomic analyses of signaling changes across various mouse tissues in response to short-term stimulation with the Egfr ligand Egf. We show how both baseline and Egf-stimulated signaling behaviors differ between tissues. Moreover, we propose how baseline phosphorylation and total protein levels may be associated with clinically relevant tissue-specific Egfr-associated phenotypes. Altogether, our analyses illustrate tissue-specific effects of Egf stimulation and highlight potential links between underlying tissue biology and Egfr signaling output.
HostingRepositoryPRIDE
AnnounceDate2025-03-08
AnnouncementXMLSubmission_2025-03-08_11:30:46.565.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJoao Paulo
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetic acid derivatized residue
InstrumentOrbitrap Eclipse; Orbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-06 05:54:26ID requested
12025-03-08 11:30:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, multi-omics, tissue specificity,Egf, MAPK, phosphoproteomics, Egfr
Contact List
Kevin M. Haigis
contact affiliationDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA. Department of Cancer Biology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA.
contact emailKevin_Haigis@dfci.harvard.edu
lab head
Joao Paulo
contact affiliationHarvard Medical School
contact emailjoao_paulo@post.harvard.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
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