PXD050235

PXD050235 is an original dataset announced via ProteomeXchange.

Title	Discovery, target identification and lead optimisation of a quinazoline series with potent anti-Chagasic activity
Description	We next used an approach to determine the direct binding of quinazolines to their target(s). A protein can be stabilised or destabilised through the binding of a ligand, altering that proteins thermostability. Such alterations in thermostability can cause a ligated protein to denature at a different temperature from its unligated counterpart (Corpas-Lopez and Wyllie, 2021; Paradela et al., 2021; Lima et al., 2022; Milne et al., 2022; Hanna et al., 2023). Isothermal proteome profiling (IPP), which detects changes in protein thermostability following the addition of drug to a lysate, was used to determine which proteins from the entire T. cruzi proteome bind to Q371 and Bhambra-10.3.
HostingRepository	PRIDE
AnnounceDate	2025-04-22
AnnouncementXML	Submission_2025-04-22_02:50:49.331.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Victoriano Corpas-Lopez
SpeciesList	scientific name: Trypanosoma cruzi Dm28c; NCBI TaxID: 1416333;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-29 03:38:12	ID requested
⏵ 1	2025-04-22 02:50:49	announced

Dataset with its publication pending

submitter keyword: drug target, trypanosoma cruzi,thermal proteome profiling

Susan Wyllie
contact affiliation	WCAIR, School of Life Sciences, University of Dundee
contact email	swyllie@dundee.ac.uk
lab head
Victoriano Corpas-Lopez
contact affiliation	University of Dundee
contact email	vcorpaslopez@dundee.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD050235

PRIDE project URI

• PRIDE
  1. PXD050235
     1. Label: PRIDE project
     2. Name: Discovery, target identification and lead optimisation of a quinazoline series with potent anti-Chagasic activity