PXD050231

PXD050231 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of allergic march in children
Description	Identifying children at risk of developing asthma is crucial in guiding targeted preventive therapies. In recent years, researchers have proposed several candidate biomarkers for predicting AM. One such biomarker is fatty-acid-binding protein 5 (FABP5), which correlates with interleukin-17A levels in both the skin and serum, suggesting its potential as a biomarker for AM. Specific IgE, skin prick tests, and cytokine ratios show promise in predicting asthma development.3 However, while these proposed biomarkers are the subject of research on the skin, no biomarkers are identified through blood proteomics. Although AD may initially result from skin barrier dysfunction, systemic sensitization and changes in systemic immune response may predominantly contribute to asthma after AD. Therefore, this study aims to identify blood biomarkers in early life to predict AM progression among infants initially diagnosed with AD. The study participants included 20 healthy controls, 15 with AD, 11 with asthma, and 21 with AM (children aged 7 years old). All participants were diagnosed with asthma, and a history of AD was confirmed by a physician. The protein expression profiles in plasma samples collected from 3-year-olds before the onset of AM were evaluated using sequential window acquisition of all theoretical mass spectra.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_13:41:31.376.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jeonghun Yeom
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-28 21:27:27	ID requested
⏵ 1	2025-05-06 13:41:32	announced

10.1002/ppul.27349;

Kang MJ, Kwak DH, Park H, Kim H, Yeom J, Lee SY, Choi SS, Hong SJ, Predictive biomarker for allergic March in children using blood proteomics. Pediatr Pulmonol, 60(1):e27349(2025) [pubmed]

submitter keyword: Prediction,Allergic march, Proteomics

Jeonghun Yeom
contact affiliation	Prometabio Research Institute, prometabio co., ltd.
contact email	nature918@prometabio.com
lab head
Jeonghun Yeom
contact affiliation	prometabio co., ltd.
contact email	nature8309@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050231

PRIDE project URI

• PRIDE
  1. PXD050231
     1. Label: PRIDE project
     2. Name: Proteomic profiling of allergic march in children