PXD050228

PXD050228 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling and Biomarker Discovery for Predicting Response to PD-1 Inhibitor Immunotherapy in Gastric Cancer Patients
Description	Revolutionizing cancer treatment, immune checkpoint inhibitors (ICIs) have nonetheless encountered a challenge: a substantial portion of gastric cancer (GC) patients don’t respond to this therapy. This pressing issue necessitates a deeper understanding of the resistance mechanisms against ICIs and the identification of robust biomarkers that can predict patient response to ICIs from the outset of treatment. In our project, we collected GC tissue samples from 28 patients prior to their initiation of anti-programmed death 1 (PD-1) immunotherapy. Employing high-resolution mass spectrometry (MS), we conducted comprehensive protein quantification. We then proceeded to analyze the disparities in protein expression profiles, associated pathways, and the characteristics of the tumor microenvironment (TME) between responder and non-responder groups. Ultimately, our aim is to delve into the mechanisms that give rise to differential therapeutic efficacy and thereby uncover reliable biomarkers for predicting ICI response in GC patients.
HostingRepository	iProX
AnnounceDate	2024-02-29
AnnouncementXML	Submission_2024-10-17_20:29:10.943.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiangang Sun
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-28 18:40:28	ID requested
⏵ 1	2024-10-17 20:29:11	announced

Sun J, Li X, Wang Q, Chen P, Zhao L, Gao Y, Proteomic profiling and biomarker discovery for predicting the response to PD-1 inhibitor immunotherapy in gastric cancer patients. Front Pharmacol, 15():1349459(2024) [pubmed]

submitter keyword: Gastric cancer, immune checkpoint inhibitor, proteomic, biomarker

Jiangang Sun
contact affiliation	The First Affiliated Hospital of Zhengzhou University
contact email	fccsjgang@zzu.edu.cn
lab head
Jiangang Sun
contact affiliation	The First Affiliated Hospital of Zhengzhou University
contact email	fccsjgang@zzu.edu.cn
dataset submitter

iProX dataset URI