PXD050226

PXD050226 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Diving into the proteomic atlas of SARS-CoV-2 infected cells: insights of viral infection in different cell types
Description	The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as a respiratory disease, SARS-CoV-2 infects multiple tissues throughout the human body, leading to a wide range of symptoms in patients. To better understand how SARS-CoV-2 affects the proteome from cells with different ontologies, this work generated an infectome atlas of 9 cell models, including cells from brain, blood, digestive system, and adipocyte tissue. Our data shows that SARS-CoV-2 infection mainly trigger dysregulations on proteins related to cellular structure and energy metabolism. Despite these pivotal processes, heterogeneity of infection was also observed, highlighting many proteins and pathways uniquely dysregulated in one cell type or ontological group. These data have been made searchable online via a tool that will permit future submissions of proteomic data (https://reisdeoliveira.shinyapps.io/Infectome_App/) to enrich and expand this knowledgebase.
HostingRepository	PRIDE
AnnounceDate	2024-02-29
AnnouncementXML	Submission_2024-02-29_07:42:04.657.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD050226
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Licia C. Silva-Costa
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-28 14:26:49	ID requested
⏵ 1	2024-02-29 07:42:05	announced

Publication List

10.1002/JCP.31199;
10.6019/PXD050226;

10.1002/JCP.31199;

10.6019/PXD050226;

Keyword List

submitter keyword: COVID-19 Sars-Cov2 Infectome Proteomics Infected cells

submitter keyword: COVID-19 Sars-Cov2 Infectome Proteomics Infected cells

Contact List

Daniel Martins-de-Souza
contact affiliation	Laboratory of Neuroproteomics, DBBT, IB, Universidade Estadual de Campinas, Brazil
contact email	dmsouza@unicamp.br
lab head
Licia C. Silva-Costa
contact affiliation	Unicamp
contact email	l065387@g.unicamp.br
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD050226
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD050226

PRIDE project URI

Repository Record List

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