PXD050180

PXD050180 is an original dataset announced via ProteomeXchange.

Title	The Atlantic cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II
Description	Atlantic cod and codfish (Gadiformes) lack major histocompatibility complex (MHC) class II and CD4+ T cells, components of the immune system that are central to autoimmune diseases and to fight bacterial infections. In mammalians, the MHC class II molecules are expressed in cells of the immune system like B cells, monocytes, macrophages and dendritic cells. Here, the MHC class II molecules control the specificity of the immune response by presenting fragments from proteins that are degraded in the endosomal pathway to CD4+ T cells. In the absence of MHC class II, such as in bare lymphocyte syndrome type II patients and in MHC class II-deficient mice, the immune system fails to respond properly to infections, ultimately leading to life-threatening conditions. It remains a mystery then, how codfish lacking the MHC class II pathway, can efficiently fight diseases. By studying Atlantic cod MHC I in cod cell lines and primary cells, we aim to search for and determine the function of new players and pathways that might compensate for the absence of the MHC class II pathway.
HostingRepository	PRIDE
AnnounceDate	2025-05-13
AnnouncementXML	Submission_2025-05-13_06:06:44.381.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manuel Ramirez
SpeciesList	scientific name: Gadus morhua (Atlantic cod); NCBI TaxID: 8049;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker software

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-27 02:32:35	ID requested
⏵ 1	2025-05-13 06:06:45	announced

10.1038/s41598-024-76225-z;

Bj, ø, rnestad SA, Solbakken MH, Krokene P, Thiede B, Hylland K, Jakobsen KS, Jentoft S, Bakke O, Progida C, The Atlantic Cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II. Sci Rep, 14(1):25404(2024) [pubmed]

submitter keyword: cross-presentation, MHC I,Atlantic cod, endosomal pathway

Cinzia Anita Maria Progida
contact affiliation	Department of Biosciences, University of Oslo, Oslo, Norway
contact email	c.a.m.progida@ibv.uio.no
lab head
Manuel Ramirez
contact affiliation	University of Oslo
contact email	manuelra@uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050180

PRIDE project URI

• PRIDE
  1. PXD050180
     1. Label: PRIDE project
     2. Name: The Atlantic cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II