PXD050180 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The Atlantic cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II |
Description | Atlantic cod and codfish (Gadiformes) lack major histocompatibility complex (MHC) class II and CD4+ T cells, components of the immune system that are central to autoimmune diseases and to fight bacterial infections. In mammalians, the MHC class II molecules are expressed in cells of the immune system like B cells, monocytes, macrophages and dendritic cells. Here, the MHC class II molecules control the specificity of the immune response by presenting fragments from proteins that are degraded in the endosomal pathway to CD4+ T cells. In the absence of MHC class II, such as in bare lymphocyte syndrome type II patients and in MHC class II-deficient mice, the immune system fails to respond properly to infections, ultimately leading to life-threatening conditions. It remains a mystery then, how codfish lacking the MHC class II pathway, can efficiently fight diseases. By studying Atlantic cod MHC I in cod cell lines and primary cells, we aim to search for and determine the function of new players and pathways that might compensate for the absence of the MHC class II pathway. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-13 |
AnnouncementXML | Submission_2025-05-13_06:06:44.381.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Manuel Ramirez |
SpeciesList | scientific name: Gadus morhua (Atlantic cod); NCBI TaxID: 8049; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Bruker software |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-27 02:32:35 | ID requested | |
⏵ 1 | 2025-05-13 06:06:45 | announced | |
Publication List
10.1038/s41598-024-76225-z; |
Bj, ΓΈ, rnestad SA, Solbakken MH, Krokene P, Thiede B, Hylland K, Jakobsen KS, Jentoft S, Bakke O, Progida C, The Atlantic Cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II. Sci Rep, 14(1):25404(2024) [pubmed] |
Keyword List
submitter keyword: cross-presentation, MHC I,Atlantic cod, endosomal pathway |
Contact List
Cinzia Anita Maria Progida |
contact affiliation | Department of Biosciences, University of Oslo, Oslo, Norway |
contact email | c.a.m.progida@ibv.uio.no |
lab head | |
Manuel Ramirez |
contact affiliation | University of Oslo |
contact email | manuelra@uio.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050180 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050180
- Label: PRIDE project
- Name: The Atlantic cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II