PXD050010

PXD050010 is an original dataset announced via ProteomeXchange.

Title	MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma
Description	Multiple myeloma is an incurable hematological malignancy evolving from precursor states to advanced phases of the disease. MYC abnormalities play a critical role in the disease progression. Nevertheless, MYC lacks therapeutic drugability, thereby necessitating the exploration of alternative strategies aimed at circumventing the challenges associated with targeting MYC. In this study, we hypothesized that MYC upregulation induces genomic dependencies in tumor cells, creating vulnerabilities that can be exploited therapeutically. We discovered a differential dependency on glutamine metabolism in MYC overexpressing cells. We functionally explored these dependencies as a selective targetable vulnerability in vitro and in vivo. Furthermore, we uncovered a potential synergistic combination that can exacerbated this metabolic vulnerability, Collectively, our in vitro and in vivo results revealed an effective therapeutic combinatory strategy in the context of MYC overexpressing MM.
HostingRepository	PRIDE
AnnounceDate	2024-04-09
AnnouncementXML	Submission_2024-04-09_05:17:01.191.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lama Hasan Bou Issa
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-21 09:47:02	ID requested
⏵ 1	2024-04-09 05:17:02	announced

Hasan Bou Issa L, Fl, é, chon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial IM, Kluza J, Manier S, MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma. iScience, 27(4):109417(2024) [pubmed]

10.1016/j.isci.2024.109417;

submitter keyword: TMT spectrometry,MYC, U266, GLS1, NAMPT, gene dependency, MYC overexpression, cellular metabolism, multiple myeloma

Salomon Manier
contact affiliation	1Canther, INSERM UMR-S1277 and CNRS UMR9020, Lille University, Lille 59000, France 2Department of Hematology, CHU Lille
contact email	salomon.manier@inserm.fr
lab head
Lama Hasan Bou Issa
contact affiliation	Canther, INSERM UMR-S1277 and CNRS UMR9020, Lille University
contact email	lama.hasan-bou-issa@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD050010

PRIDE project URI

• PRIDE
  1. PXD050010
     1. Label: PRIDE project
     2. Name: MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma