PXD049987

PXD049987 is an original dataset announced via ProteomeXchange.

Title	Intrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling
Description	Short-term intrauterine hyperglycaemia significantly reduced lean mass in male offspring at 8 weeks, resulting in decreased exercise endurance and metabolic disorders. Disrupted organization and function of the mitochondria in skeletal muscle were also observed among them. Foetal exposure to hyperglycaemia decreased phosphorylated CREB and reduced the transcription of Ppargc1a.
HostingRepository	PRIDE
AnnounceDate	2024-08-09
AnnouncementXML	Submission_2024-08-09_05:07:24.839.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi-Shang Yan
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-21 06:52:32	ID requested
⏵ 1	2024-08-09 05:07:25	announced

Yan YS, Mo JY, Huang YT, Zhu H, Wu HY, Lin ZL, Liu R, Liu XQ, Lv PP, Feng C, Sheng JZ, Jin M, Huang HF, Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling. Nutr Diabetes, 14(1):56(2024) [pubmed]

10.1038/s41387-024-00299-x;

submitter keyword: mouse embryonic skeletal muscle in limb

Yi-Shang Yan
contact affiliation	The second affiliated hospital, school of medicine, Zhejiang University, Hangzhou, China;
contact email	yanyishang@zju.edu.cn
lab head
Yi-Shang Yan
contact affiliation	Second Affiliated Hospital of Zhejiang University
contact email	yanyishang@zju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD049987

PRIDE project URI

• PRIDE
  1. PXD049987
     1. Label: PRIDE project
     2. Name: Intrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling