PXD049973
PXD049973 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Extracellular Glutathione Peroxidase 3 GPx3 Levels are Markedly Reduced in Children Affected with Konzo an Irreversible Spastic Paralysis Associated with Food Poisoning |
Description | Konzo, a neglected paralytic neurological disease associated with food (cassava) poisoning, affects the world poorest children and women of childbearing ages across regions of sub Saharan Africa, with the Democratic Republic of the Congo having the largest case burden. The primary risk factors for development include a dietary reliance on cyanogenic rich cassava and malnutrition, factors which are exacerbated by environmental stressors such as drought and famine. Despite understanding the dietary risks that lead to konzo, the molecular markers and mechanisms that trigger this disease remain unknown. Plasma, collected from two large independent cohorts 10 years apart, were subjected to multiple high throughput mass spectrometry in search of disease biomarkers and proteins that were differentially expressed in children affected with konzo relative to those unaffected, including their siblings. DDA experiment was performed on the first cohort with a validation by SRM analysis. For the second cohort, DIA experiment was performed with a validation by PRM. |
HostingRepository | MassIVE |
AnnounceDate | 2024-08-12 |
AnnouncementXML | Submission_2024-08-12_13:28:18.702.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Victor Fourcassie |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion; TSQ Altis; Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-02-20 12:11:40 | ID requested | |
⏵ 1 | 2024-08-12 13:28:19 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Konzo disease, GPx3, Oxidative stress, Plasma proteomics |
Contact List
Arnaud Droit | |
---|---|
contact affiliation | CHU de Quebec Universite Laval |
contact email | arnaud.droit@crchuq.ulaval.ca |
lab head | |
Victor Fourcassie | |
contact affiliation | CHUL Proteomics Platform |
contact email | victor.fourcassie@crchudequebec.ulaval.ca |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094134/ |