PXD049972

PXD049972 is an original dataset announced via ProteomeXchange.

Title	Evaluation of the impact of the dietary inclusion of salty and sugary former food products on the liver and plasma profile of pigs through OMICS approaches
Description	The research on alternative and sustainable feed ingredients is a challenge to reduce feed-food competition between humans and monogastrics, in particular pigs. Former food products (FFPs) drop out from the industrial production of food such as pasta, bread, snacks, and chips. They have a high nutritional and energetic value and represent an alternative and sustainable feed ingredient. The aim of this study was to apply omics tools to assess the impact of the dietary inclusion of FFPs in pigs’ diet. For the in vivo trial, thirty-six Swiss Large White male castrated pigs were randomly assigned to three dietary groups: control (CTR), 30% replacement of CTR diet with salty FFPs (SA), 30% replacement of CTR diet with sugary FFPs (SU). The trial lasted from the start of the growing phase (22.4 ± 1.7 kg) until slaughtering phase (110 ± 3 kg). After slaughtering, blood and liver tissue samples were collected and processed according to the omics approaches used. The number of differentially regulated proteins in each comparison matrix (SA/SU vs. CTR) indicated a marginal impact on liver function, as measured by proteomics on tissue samples. The peptidomics investigation on plasma samples showed low variability between the peptidome of the three dietary groups and identified three possible bioactive peptides associated with anti-hypertension in the SA dietary group. To conclude, the safety and the limited impact of the SA and SU diets on liver proteome and plasma peptidome strengthened the idea of recycling FFPs as feed ingredients to make pig production more sustainable.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_05:31:48.360.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alessandra Altomare
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-20 12:11:24	ID requested
⏵ 1	2024-10-17 05:31:49	announced

10.1038/s41598-024-70310-z;

Manoni M, Altomare A, Nonnis S, Ferrario G, Mazzoleni S, Tretola M, Bee G, Tedeschi G, Aldini G, Pinotti L, Preliminary investigation on the impact of salty and sugary former foods on pig liver and plasma profiles using OMICS approaches. Sci Rep, 14(1):19386(2024) [pubmed]

submitter keyword: Former food products, Peptidomics, Plasma, Proteomics, Pigs, Liver

Alessandra Altomare
contact affiliation	Department of Pharmaceutical Sciences, University of Milan
contact email	alessandra.altomare@unimi.it
lab head
Alessandra Altomare
contact affiliation	University of Milan (DISFARM)
contact email	alessandra.altomare@unimi.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD049972

PRIDE project URI

• PRIDE
  1. PXD049972
     1. Label: PRIDE project
     2. Name: Evaluation of the impact of the dietary inclusion of salty and sugary former food products on the liver and plasma profile of pigs through OMICS approaches