PXD049688

PXD049688 is an original dataset announced via ProteomeXchange.

Title	urinary glycopeptide profile differentiates early cardiorenal risk in subjects not meeting criteria for chronic kidney disease
Description	Early diagnosis and treatment of chronic kidney disease (CKD) is a worldwide challenge. Albuminuria is defined as urinary albumin:creatinine ratio (ACR) ≥30 mg/g. Subjects with ACR values below this cut-off and preserved renal function are considered at no cardiorenal risk, but increased risk is established even at the 10-30 mg/g ACR range, supporting the need to identify other molecular indicators for early assessment of normoalbuminuric patients at higher risk. Following our previous studies, here we aimed to stratify the normoalbuminuria range according to cardiorenal risk and identify glycoproteins and N-glycosylation sites associated to kidney damage in subclinical CKD.
HostingRepository	PRIDE
AnnounceDate	2025-06-02
AnnouncementXML	Submission_2025-06-01_16:07:14.164.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan A Lopez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-19 07:40:53	ID requested
⏵ 1	2025-06-01 16:07:15	announced

10.3390/ijms25137005;

Santiago-Hernandez A, Martin-Lorenzo M, G, ó, mez-Serrano M, Lopez JA, Martin-Blazquez A, Vellosillo P, Minguez P, Martinez PJ, V, á, zquez J, Ruiz-Hurtado G, Barderas MG, Sarafidis P, Segura J, Ruilope LM, Alvarez-Llamas G, The Urinary Glycopeptide Profile Differentiates Early Cardiorenal Risk in Subjects Not Meeting Criteria for Chronic Kidney Disease. Int J Mol Sci, 25(13):(2024) [pubmed]

submitter keyword: Urine

glycopeptide

chronic kidney disease

early cardiorenal risk;albuminuria

Juan A Lopez
contact affiliation	Proteomics Unit
contact email	jalopez@cnic.es
lab head
Juan A Lopez
contact affiliation	CNIC
contact email	jalopez@cnic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD049688

PRIDE project URI

• PRIDE
  1. PXD049688
     1. Label: PRIDE project
     2. Name: urinary glycopeptide profile differentiates early cardiorenal risk in subjects not meeting criteria for chronic kidney disease