PXD049472 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human Hippo cancer mutation proteins TAP-LC-MS |
Description | The Hippo pathway is a commonly altered signaling pathway involved in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development has not been fully understood. In this study, we systematically analyzed the Hippo somatic mutations derived from human cancer genome and functionally annotated their roles in targeting the Hippo pathway. We identified a total of 85 driver missense mutations for the major Hippo pathway genes and elucidated the mechanisms by which these mutations altered their functions in the Hippo pathway. Through these analyses, we revealed zinc-finger domain (ZNF) as an integral structure required for MOB1 function, whose driver mutations promoted head and neck cancer development. Moreover, we discovered that the schwannoma/meningioma-derived NF2 driver mutations gained an oncogenic role by activating the VANGL-JNK pathway. Taken together, our study offers a rich somatic mutation resource for further investigating the Hippo pathway in human cancer, providing a molecular basis for the development of Hippo-related personalized cancer therapy. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-18 |
AnnouncementXML | Submission_2024-10-18_01:41:45.599.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD049472 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | HAN HAN |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-19 02:35:56 | ID requested | |
⏵ 1 | 2024-10-18 01:41:46 | announced | |
Publication List
Keyword List
submitter keyword: Somatic mutations, Cancer,The Hippo pathway |
Contact List
Wenqi Wang |
contact affiliation | Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA |
contact email | wenqiw6@uci.edu |
lab head | |
HAN HAN |
contact affiliation | TaiKang Medical School, Wuhan University |
contact email | hanhan@whu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049472
- Label: PRIDE project
- Name: Human Hippo cancer mutation proteins TAP-LC-MS