PXD049472

PXD049472 is an original dataset announced via ProteomeXchange.

Title	Human Hippo cancer mutation proteins TAP-LC-MS
Description	The Hippo pathway is a commonly altered signaling pathway involved in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development has not been fully understood. In this study, we systematically analyzed the Hippo somatic mutations derived from human cancer genome and functionally annotated their roles in targeting the Hippo pathway. We identified a total of 85 driver missense mutations for the major Hippo pathway genes and elucidated the mechanisms by which these mutations altered their functions in the Hippo pathway. Through these analyses, we revealed zinc-finger domain (ZNF) as an integral structure required for MOB1 function, whose driver mutations promoted head and neck cancer development. Moreover, we discovered that the schwannoma/meningioma-derived NF2 driver mutations gained an oncogenic role by activating the VANGL-JNK pathway. Taken together, our study offers a rich somatic mutation resource for further investigating the Hippo pathway in human cancer, providing a molecular basis for the development of Hippo-related personalized cancer therapy.
HostingRepository	PRIDE
AnnounceDate	2024-10-18
AnnouncementXML	Submission_2024-10-18_01:41:45.599.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD049472
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	HAN HAN
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-19 02:35:56	ID requested
⏵ 1	2024-10-18 01:41:46	announced

10.6019/PXD049472;

submitter keyword: Somatic mutations, Cancer,The Hippo pathway

Wenqi Wang
contact affiliation	Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA
contact email	wenqiw6@uci.edu
lab head
HAN HAN
contact affiliation	TaiKang Medical School, Wuhan University
contact email	hanhan@whu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD049472

PRIDE project URI

• PRIDE
  1. PXD049472
     1. Label: PRIDE project
     2. Name: Human Hippo cancer mutation proteins TAP-LC-MS