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PXD049472

PXD049472 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman Hippo cancer mutation proteins TAP-LC-MS
DescriptionThe Hippo pathway is a commonly altered signaling pathway involved in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development has not been fully understood. In this study, we systematically analyzed the Hippo somatic mutations derived from human cancer genome and functionally annotated their roles in targeting the Hippo pathway. We identified a total of 85 driver missense mutations for the major Hippo pathway genes and elucidated the mechanisms by which these mutations altered their functions in the Hippo pathway. Through these analyses, we revealed zinc-finger domain (ZNF) as an integral structure required for MOB1 function, whose driver mutations promoted head and neck cancer development. Moreover, we discovered that the schwannoma/meningioma-derived NF2 driver mutations gained an oncogenic role by activating the VANGL-JNK pathway. Taken together, our study offers a rich somatic mutation resource for further investigating the Hippo pathway in human cancer, providing a molecular basis for the development of Hippo-related personalized cancer therapy.
HostingRepositoryPRIDE
AnnounceDate2024-10-18
AnnouncementXMLSubmission_2024-10-18_01:41:45.599.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD049472
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHAN HAN
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-02-19 02:35:56ID requested
12024-10-18 01:41:46announced
Publication List
10.6019/PXD049472;
Keyword List
submitter keyword: Somatic mutations, Cancer,The Hippo pathway
Contact List
Wenqi Wang
contact affiliationDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA
contact emailwenqiw6@uci.edu
lab head
HAN HAN
contact affiliationTaiKang Medical School, Wuhan University
contact emailhanhan@whu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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