PXD049469

PXD049469 is an original dataset announced via ProteomeXchange.

Title	Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice
Description	Polypharmacy (use of 5 or more concurrent medications) is highly prevalent among older adults to manage chronic diseases and is linked to adverse geriatric outcomes, including physical and cognitive functional impairments, falls, frailty, hospitalization, and mortality. Deprescribing (withdrawal) is a potential strategy to manage polypharmacy. The broad molecular changes by which polypharmacy causes harm and deprescribing may be beneficial are unknown and unfeasible to study rigorously in tissue from geriatric patients. Therefore, in a randomized controlled trial, we administered therapeutic doses of commonly used chronic medications (oxycodone, oxybutynin, citalopram, simvastatin, or metoprolol) as monotherapy or concurrently (as polypharmacy) from middle-age (12 months) to old age (26 months) to male C57BL/6J (B6) mice and deprescribed (gradually withdrew) treatments in a subset from age 21 months. The mice were terminated at 26 months of age, and liver samples were collected for proteomics analysis.
HostingRepository	PRIDE
AnnounceDate	2024-11-12
AnnouncementXML	Submission_2024-11-11_22:58:41.069.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Mach
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-18 18:19:28	ID requested
⏵ 1	2024-11-11 22:58:41	announced

10.1111/acel.14357;

Winardi K, Mach J, McKay MJ, Molloy MP, Mitchell SJ, MacArthur MR, McKenzie C, Le Couteur DG, Hilmer SN, Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice. Aging Cell, 24(1):e14357(2025) [pubmed]

submitter keyword: Aging, Deprescribing, Citalopram, Mouse, Simvastatin, Oxybutynin, Metoprolol,Polypharmacy, DIA, Drug Response, LC-MS, Oxycodone, Liver

Prof Sarah N Hilmer
contact affiliation	Laboratory of Ageing and Pharmacology, Kolling Institute, The University of Sydney
contact email	sarah.hilmer@sydney.edu.au
lab head
John Mach
contact affiliation	The University of Sydney, Kolling Institute
contact email	john.mach@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD049469

PRIDE project URI

• PRIDE
  1. PXD049469
     1. Label: PRIDE project
     2. Name: Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice